To systematically evaluate the efficacy of Rhizoma Curcumae and its active components on experimental liver fibrosis，and to provide evidence for clinical treatment.Methods:Searching Chinese and English databases such as CNKI，Wanfang，VIP，Pubmed，Embase，Cochrane Library and CBM by computer，the Chinese literature on Rhizoma Curcumae and its active ingredients for the treatment of experimental liver fibrosis using randomized controlled trial was collected from the establishment of the databases till January 2020.The intervention group included Rhizoma curcumae water decoction，vinegar baked Rhizoma curcumae，Rhizoma curcumae extracts，Curcuma polysaccharides，curcuma alcohol，curcumin，β-elemene and so on.The outcome measures included liver function，liver fibrosis，liver index and related physical and chemical indexes.After screening,data were analyzed by two researchers using Review Manager 5.3.Results:A total of 11 RCTs tests were included，including 196 cases.The results of Meta analysis showed that ALT(MD-0.58，95%CI:-1.29 to -0.04；P=0.33; n=4，I2=12%)，AST(MD-0.83，95%CI:-1.39 to -0.27; P=0.29; n=4，I2=20%)were significantly lower in the intervention group than in the model group，while increased TP(MD8.36，95%CI：6.20 to 10.51; n=2，I2=0%)，ALB(MD2.19，95%CI：1.39 to 2.98; P=0.25; n=4，I2=27%)improved liver function.The improvement of 4 indexes of hepatic fibrosis，HA(MD-177.45，95%CI:-187.81 to -167.09; n=3，I2=0%)，LN(MD-1.57，95%CI:-2.37 to -0.77; n=2，I2=0%)，PCⅢ(MD-4.54，95%CI:-5.90 to -3.18; n=2，I2=0%)，Ⅳ-C(MD-2.23，95%CI:-3.11 to -1.35; n=2，I2=0%)，were better than those of the model group in the intervention group.The liver index(MD-6.79，95%CI:-8.75 to -4.83; n=2，I2=0%)was effectively reduced，and the liver fibrosis was inhibited by regulating the expression of related physical and chemical factors(α-SMA、HYP、MDA、TGF-β1、SOD).Conclusion:Rhizoma Curcumae and its effective components have efficacy on experimental liver fibrosis，but it still needs to be validated by large sample and multi-center RCT study.