To explore the effects of treating acute exacerbation of chronic obstructive pulmonary disease（syndrome of phlegm-heat obstructing lung）patients with Sangbaipi Decoction，and to explore the influence on lung function and blood qi analysis.Methods:A total of 80 patients with phlegm-heat obstructed lung type in the acute exacerbation stage of COPD from January 2016 to December 2018 were selected as the research objects and were randomly divided into a control and an observation groups according to the random number table method，with 40 cases in each group.Patients in the control group were given conventional Western medicine treatment，and patients in the observation group were given modified Sangbaipi Decoction on the basis of the control group.The course of the treatment was 2 weeks.The clinical efficacy of the 2 groups of patients was analyzed by TCM syndrome scores，the pulmonary ventilation function and arterial blood gas indicators were measured，the serum inflammatory indicator were monitored，and the adverse reactions during medication were collected.Results:The control group had a clinical control rate of 25.00% and an effective rate of 75.00%.The clinical control rate was 47.50% and the effective rate was 92.50%(P＜0.05).After treatment，the symptom relief，pulmonary ventilation function and arterial blood qi improvement were more obvious in the observation group，and the TCM syndrome score of wheezing，cough，cough and other main symptoms was significantly lower than that of the control group(P<0.05).The levels of pulmonary function indicators were significantly higher than those of the control group，while RI levels were significantly lower(P<0.05).The SaO2 and PaO2 levels were significantly higher than the control group，the level of PaCO2 was significantly lower than the control group(P<0.05)，the airway inflammation of the observation group was significantly reduced，and the serum levels of PCT，TWEAK，IL-1β and IL-17A were significantly decreased(P<0.05).The incidence of adverse reactions in the observation group was 17.50%，in the control group of 12.50%，but the difference was not statistically significant(P<0.05).Conclusion:Modified Sangbaipi Decoction has definite curative effect on patients with acute exacerbation of chronic obstructive pulmonary disease，which is conducive to relieving the symptoms，improving the pulmonary ventilation function and arterial blood qi status，and reducing airway inflammation，which has high drug safety and worthy of clinical promotion.