| 引用本文:牛芊1，邢文龙2，刘红旭2，王雨桐3，朱彦4.丹红注射液对不稳定型心绞痛患者围手术期代谢组学的影响[J].世界中医药,2021,(12):. |
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| 丹红注射液对不稳定型心绞痛患者围手术期代谢组学的影响 |
| Effects of Danhong Injection on Perioperative Metabolomics in Patients with Unstable Angina Pectoris |
| 投稿时间：2020-06-08 |
| DOI：10.3969/j.issn.1673-7202.2021.12.001 |
| 中文关键词: 不稳定型心绞痛 血瘀证 丹红注射液 代谢组学 代谢通路 经皮冠状动脉介入治疗 围手术期 临床研究 心肌保护 |
| English Keywords:Unstable angina pectoris Prethrombotic state Danhong Injection Metabolomics Metabolic pathway Perioperative PCI Perioperative period Clinical research Myocardial protection |
| 基金项目:国家自然科学基金面上项目（81273741）；北京市自然科学基金项目（7142077）；许夏基金项目（XX-201710）；北京中医医院院级课题暨两院合作课题（YJ201720） |
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| 中文摘要: |
| 目的：观察丹红注射液对不稳定型心绞痛（Unstable Angina Pectoris，UA）血瘀证患者择期经皮冠状动脉介入治疗（Percutaneous CoronaryIntervention，PCI）围手术期血清代谢组学的影响。方法：采用前瞻性、随机、对照、单盲的临床研究方法，选取2018年7月至2019年1月首都医科大学附属北京中医医院行PCI的中医证属血瘀证的UA患者61例作为研究对象，采用随机数字表法随机分为丹红组（n=31）和对照组（n=30）。丹红组采用西医规范治疗+丹红注射液治疗，对照组采用西医规范治疗+生理盐水，纳入健康志愿者10例。应用非靶向代谢组学方法对丹红组、对照组治疗前、PCI术后5 d及健康志愿者血清代谢产物进行分析。结果：治疗前，丹红组与对照组血清代谢产物谱比较，差异无统计学意义（P>0.05）；治疗前，丹红组及对照组与健康组有较大的差异，差异代谢物包括甘油磷脂代谢、鞘脂代谢、嘌呤代谢、氨基酸代谢等代谢通路中相关代谢产物；PCI术后5 d，丹红组与对照组患者的血清代谢物谱均趋向健康组，与治疗前比较差异有统计学意义（P<0.05）；术后丹红组患者的血清代谢物谱较对照组更接近健康组水平，差异有统计学意义（P<0.05）。结论：在西医规范治疗基础上使用丹红注射液，可使患者血清代谢产物水平更接近健康人群。 |
| English Summary: |
| To observe the effects of Danhong Injection on perioperative serum metabonomics in patients with blood stasis syndrome of unstable angina pectoris(UA)by using percutaneous coronary intervention(PCI) in a certain period.Methods:A prospective,randomized,controlled,single blind clinical trial was conducted.A total of 61 UA patients with TCM blood stasis syndrome undergoing elective PCI were selected as the research objects and were randomly divided into a Danhong group(n=31) and a control group(n=30),and 10 healthy volunteers were included as baseline.Danhong group received Western medicine+DHI treatment,the control group received Western medicine+saline.Non-targeted metabolomics methods were used to analyze the serum metabolites of Danhong group,and control group before treatment,5 days after PCI and serum metabolites of healthy volunteers.Results:Before treatment,there was no significant difference in serum metabolites between the Danhong group and the control group.Before treatment,there was significant difference among the above 2 groups and the healthy group.Differential metabolites mainly included glycerophospholipid,sphingolipid,purine,and amino acid groups,which were generated in their metabolic pathways.After 5 days of PCI,the profiles of serum metabolites were significantly closer to the healthy group.Compared with before treatment,there was a statistical difference; the serum metabolite profile of patients in the Danhong group was closer to the level of the healthy group than the control group,and the difference was statistically significant.Conclusion:The use of Danhong Injection on the basis of Western medicine standard treatment can make the patient's serum metabolite level closer to healthy people. |
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