To observe the effects of Danhong Injection on perioperative serum metabonomics in patients with blood stasis syndrome of unstable angina pectoris(UA)by using percutaneous coronary intervention(PCI) in a certain period.Methods:A prospective,randomized,controlled,single blind clinical trial was conducted.A total of 61 UA patients with TCM blood stasis syndrome undergoing elective PCI were selected as the research objects and were randomly divided into a Danhong group(n=31) and a control group(n=30),and 10 healthy volunteers were included as baseline.Danhong group received Western medicine+DHI treatment,the control group received Western medicine+saline.Non-targeted metabolomics methods were used to analyze the serum metabolites of Danhong group,and control group before treatment,5 days after PCI and serum metabolites of healthy volunteers.Results:Before treatment,there was no significant difference in serum metabolites between the Danhong group and the control group.Before treatment,there was significant difference among the above 2 groups and the healthy group.Differential metabolites mainly included glycerophospholipid,sphingolipid,purine,and amino acid groups,which were generated in their metabolic pathways.After 5 days of PCI,the profiles of serum metabolites were significantly closer to the healthy group.Compared with before treatment,there was a statistical difference; the serum metabolite profile of patients in the Danhong group was closer to the level of the healthy group than the control group,and the difference was statistically significant.Conclusion:The use of Danhong Injection on the basis of Western medicine standard treatment can make the patient's serum metabolite level closer to healthy people.