| 引用本文:关永霞1，申凤霞1，李倩1，范建伟1，陈学通2，王永华3，张贵民1.半夏厚朴汤治疗反流性食管炎的系统药理学分析[J].世界中医药,2021,(13):. |
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| 半夏厚朴汤治疗反流性食管炎的系统药理学分析 |
| System Pharmacological Analysis of Banxia Houpo Decoction in Treating Reflux Esophagitis |
| 投稿时间：2020-05-18 |
| DOI：10.3969/j.issn.1673-7202.2021.13.007 |
| 中文关键词: 半夏厚朴汤 反流性食管炎 系统药理学 作用机制 靶点预测 |
| English Keywords:Banxia Houpo Decoction Reflux esophagitis System pharmacology Action mechanism Target prediction |
| 基金项目:山东省重点研发计划（重大科技创新工程）项目（2018CXGC1305） |
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| 中文摘要: |
| 目的：采用系统药理学的方法探讨半夏厚朴汤治疗反流性食管炎的有效成分、作用靶点及作用机制，为其进一步开发和临床应用提供参考。方法：利用中药系统药理学数据库与分析平台（TCMSP）和文献检索搜集半夏厚朴汤中的化学成分；运用口服生物利用度（OB）、类药性（DL）2个药代动力学参数筛选活性化合物；采用WES模型预测候选活性化合物的靶点；通过检索CTD数据库和TTD数据库，筛选出与反流性食管炎相关的靶点；GOBP富集分析；构建化合物-靶点、靶点-通路网络图。结果：构建了一个包括521个化合物的半夏厚朴汤分子数据库，通过OB、DL筛选获得65个候选活性化合物，WES模型预测出候选活性化合物的249个靶点；筛选出151个与反流性食管炎相关的靶点；GOBP富集分析得到与反流性食管炎相关的生物过程条目20个；KEGG通路富集筛选得到相关的通路11条。结论：半夏厚朴汤主要通过调控炎症、调节胃肠动力、保护胃黏膜、提高免疫力、调节胆碱能神经等来治疗反流性食管炎，半夏厚朴汤治疗反流性食管炎具有多成分、多靶点、多通路协同作用的特点，有望对反流性食管炎的治疗提供新的研究思路，为后期实验验证提供理论依据。 |
| English Summary: |
| To identify the active components，action targets and action mechanisms of Banxia Houpo Decoction in the treatment of reflux esophagitis by using systems pharmacology method，thus providing references for its further development and clinical application.Methods:Using the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database and literature search，the chemical components of Banxia Houpo Decoction was collected;then OB and DL pharmacokinetic parameters was applied to screen the active compounds;WES model was used to predict the target of candidate active compounds;by searching the CTD database and the TTD database，the targets related to reflux esophagitis were screened out，and were used for GOBP and pathway enrichment analysis;finally，the compound-target，target-pathway networks were constructed.Results:A molecular database of Banxia Houpo Decoction consisting of 521 compounds was constructed，and 65 active compounds were obtained by OB and DL screening.The WES model predicted 249 targets for the active compounds;and 151 of them were screened out as reflux esophagus Inflammation-related targets.GOBP enrichment analysis of these targets yields 20 items of biological processes related to reflux esophagitis;there were 11 signal pathways in KEGG pathway enrichment screening.Conclusion:Banxia Houpo Decoction mainly treats reflux esophagitis by regulating inflammation，modulating gastrointestinal motility，protecting gastric mucosa，improving immunity，and regulating cholinergic nerves etc.Banxia Houpo Decoction treatmenting reflux esophagitis has the characteristics of multi-component，multi-target，and multi-path synergy，which is expected to provide new research ideas for the treatment of reflux esophagitis and provide theoretical basis for later experimental verification. |
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