| 引用本文:金志春1，徐小芳1，张硕1，尹璐1，叶朝阳1，刘敏1，吴艳婷1，尹燕1，杨雅琴1，胡雅南1，郭家勇2，王亚东2.补肾健脾调和气血法中药对复发性流产抗生殖抗体及妊娠结局的影响[J].世界中医药,2021,(13):. |
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| 补肾健脾调和气血法中药对复发性流产抗生殖抗体及妊娠结局的影响 |
| Effects of Chinese Medicinal for Tonifying Kidney，Invigorating Spleen and Regulating Qi and Blood on Anti-reproductive Antibody and Pregnancy Outcome with Recurrent Spontaneous Abortion |
| 投稿时间：2020-04-12 |
| DOI：10.3969/j.issn.1673-7202.2021.13.019 |
| 中文关键词: 复发性流产 补肾健脾调和气血法 抗精子抗体 抗心磷脂抗体 抗子宫内膜抗体 抗卵巢抗体 抗绒毛膜促性腺激素抗体 抗透明带抗体 抗滋养细胞抗体 |
| English Keywords:Recurrent spontaneous abortion Tonifying kidney,invigorating spleen and regulating qi and blood method Anti-sperm antibody Anti-cardiolipin antibody Anti-endometrial antibody Anti-ovarian antibody Anti-chorionic gonadotropin antibody Anti-zona pellucida antibody Anti-trophoblast antibody |
| 基金项目:湖北省卫生厅中医药中西医结合科研项目（2012Z-Y35） |
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| 中文摘要: |
| 目的：探讨补肾健脾调和气血法中药对复发性流产（Recurrent Spontaneous Abortion，RSA）患者抗精子抗体（AS-Ab）、抗心磷脂抗体（AC-Ab）、抗子宫内膜抗体（AEM-Ab）、抗卵巢抗体（AO-Ab）、抗人绒毛膜促性腺激素抗体（AhCG-Ab）、抗透明带抗体（AZP-Ab）和抗滋养细胞抗体（AT-Ab）等7种抗生殖抗体的作用，以及改善抗生殖抗体阳性RSA患者妊娠结局的效果。方法：选取2013年5月至2018年12月湖北省妇幼保健院收治的符合研究标准的复发性流产患者505例作为研究对象，随机分为对照组（n＝249）和观察组（n＝256）。对照组采用口服醋酸泼尼松（AC-Ab阳性者联合阿司匹林）治疗，观察组采用补肾健脾调和气血法中药辨证治疗，比较治疗2个疗程时2组各抗生殖抗体转阴率，以及试孕1年内的妊娠率和妊娠成功率。结果：抗体转阴病例率和抗体转阴总体率，观察组分别为90.23%、93.99%，对照组分别为82.33%、82.96%，差异有统计学意义（P<0.05）；AhCG-Ab和AT-Ab的抗体转阴率，2组比较差异无统计学意义（P>0.05），其余抗体比较，观察组优于对照组（P<0.05）。妊娠率和妊娠成功率，观察组分别为93.36%、95.82%，对照组分别为87.95%、91.46%，观察组均优于对照组，差异有统计学意义（P<0.05）。结论：补肾健脾调和气血法中药可有效抑制多种抗生殖抗体，促进抗体转阴，并可显著提高RSA患者妊娠率和妊娠成功率。 |
| English Summary: |
| To investigate the effects of Chinese medicinal for tonifying kidney and invigorating spleen and regulating qi and blood on 7 kinds of anti-reproductive immune antibodies in patients with recurrent spontaneous abortion(RSA)，including AS-Ab，AC-Ab，AEM-Ab，AO-Ab，AhCG-Ab，AZP-Ab and AT-Ab，and to improve the pregnancy outcome of RSA patients with positive antibodies.Methods:A total of 505 patients admitted to Hubei Province Maternal and Child Health Hospital were selected as the research objects and were randomly divided into a control group(249 cases) and an observation group(256 cases).The treatment group was treated by tonifying kidney invigorating spleen and regulating qi and blood，while the control group was treated by oral prednisone(AC-Ab positive patients combined with aspirin).The observation group was treated with Chinese medicinal based on the method of invigorating the kidney，strengthening the spleen and regulating qi and blood.The negative conversion of anti-reproductive immune antibody during 2 courses of treatment，pregnancy rate and pregnancy success rate within 1 year of trial pregnancy were compared between the 2 groups.Results:The negative rate of antibody and the total rate of negative antibody were 90.23% and 93.99% in the observation group and 82.33% and 82.96% in the control group respectively.There was significant difference between the 2 groups(P<0.05).There was no significant difference in the negative rate between the 2 groups in AhCG-Ab and AT-Ab(P>0.05).There was a significant difference between the 2 groups in other antibodies(P<0.05).The observation group was better than the control group.Pregnancy rate and pregnancy success rate were 93.36% and 95.82% in the observation group and 87.95% and 91.46% in the control group respectively.The observation group was superior to the control group(P<0.05).Conclusion:Chinese medicinal of tonifying kidney invigorating spleen and regulating qi and blood could effectively inhibit many kinds of anti-reproductive immune antibodies，promote the negative transformation of antibodies，and significantly improve the pregnancy rate and pregnancy success rate of RSA patients. |
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