| 引用本文:陈翀，徐力.基于网络药理学的藤梨根治疗胃癌前病变机制[J].世界中医药,2021,(14):. |
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| 基于网络药理学的藤梨根治疗胃癌前病变机制 |
| Research on the Mechanism of Actinidia Root in the Treatment of Precancerous Lesions of Gastric Cancer Based on Network Pharmacology |
| 投稿时间：2020-05-19 |
| DOI：10.3969/j.issn.1673-7202.2021.14.004 |
| 中文关键词: 网络药理学 藤梨根 胃癌前病变 机制研究 |
| English Keywords:Internet pharmacology Actinidia root Precancerous lesions of gastric cancer Mechanism research |
| 基金项目:江苏省科技计划项目(社会发展)面上项目(BE2015691) |
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| 中文摘要: |
| 目的:运用网络药理学方法探讨藤梨根治疗胃癌前病变的物质基础和分子机制。方法:运用网络数据库对藤梨根成分靶点和胃癌前病变(PLGC)靶点进行检索筛选;利用Cytoscape3.7.2软件,构建中药成分-靶点网络;利用STRING数据库构建藤梨根治疗胃癌前病变的蛋白质-蛋白质相互作用(PPI)网络图,经拓扑分析找出核心靶点。最后对药物-疾病交集靶点进行生物通路及富集分析。结果:共收集到藤梨根6个有效成分及其218个成分靶点;胃癌前病变疾病靶点222个;药物成分和疾病的共有靶点178个;以大于平均Degree值2倍(31.30)进行拓扑分析,最终得到关键核心靶点4个:VEGFA、IL6、EGFR、TP53;基因本体(GO)富集分析和京都基因和基因组百科全书(KEGG)富集分析:藤梨根治疗胃癌前病变的靶点富集在癌症通路上数目最多;其次是PID-ATF2信号通路、肌肉细胞增殖生物过程和流体剪切应力与动脉粥样硬化途径等。结论:藤梨根治疗胃癌前病变具有多成分、多靶点、多通路的特点,其机制较为复杂,可能主要通过参与癌症途径的调节来实现其治疗作用,运用网络药理学分析藤梨根治疗胃癌前病变的物质基础和分子机制具有重要意义。 |
| English Summary: |
| To explore the material basis and molecular mechanism of Actinidia root in the treatment of gastric precancerous lesions by network pharmacology.Methods:The network database was used to search and screen the root component targets and gastric precancerous lesions targets.Cytoscape3.7.2 software was used to construct a network of Chinese medicinal components-targets network; The protein-protein interaction network (PPI) of Actinidia root for the treatment of gastric precancerous lesions was constructed by using STRING database.We found the core target through topological analysis.Finally,the biological pathway and enrichment analysis of drug-disease intersection targets were carried out.Results:A total of 6 active ingredients and 218 target spots of Actinidia arguta root and 222 targets for gastric precancerous lesions were collected; there were 178 common targets for drug components and diseases.Topological analysis was carried out with a Degree value greater than 2 times (31.30),and 4 key core targets were finally obtained：VEGFA,IL6,EGFR,TP53; Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis showed that Actinidia root had the largest number of targets in cancer pathways for the treatment of gastric precancerous lesions.The second was PID-ATF2 signaling pathway,biological process of muscle cell proliferation,fluid shear stress and atherosclerosis pathway.Conclusion:Actinidia root has the characteristics of multiple components,multiple targets and multiple pathways in the treatment of gastric precancerous lesions,and its mechanism is more complex,which may be realized mainly by participating in the regulation of cancer pathway.It is of great significance to analyze the material basis and molecular mechanism of Actinidia root in the treatment of gastric precancerous lesions by network pharmacology. |
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