| 引用本文:罗智浩1，赖钰2，蒋璐2，刘云涛2，严夏2，王大伟3.丹参注射液合用黄芪注射液治疗冠心病心绞痛的Meta分析[J].世界中医药,2021,(14):. |
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| 丹参注射液合用黄芪注射液治疗冠心病心绞痛的Meta分析 |
| Meta analysis of Danshen Injection and Huangqin Injection in the Treatment of Coronary Heart Disease with Angina Pectoris |
| 投稿时间：2019-06-14 |
| DOI：10.3969/j.issn.1673-7202.2021.14.016 |
| 中文关键词: 丹参注射液 黄芪注射液 冠心病 心绞痛 Meta分析 |
| English Keywords:Danshen Injection Huangqin Injection Coronary heart disease Angina pectoris Meta analysis |
| 基金项目:广东省中医药局科研项目(20184015) |
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| 中文摘要: |
| 目的:系统评价丹参注射液合用黄芪注射液治疗冠心病心绞痛的疗效及安全性。方法:计算机检索PudMed、Cochrane、中国学术期刊数据库(CSPD)、国家知识基础设施数据库(CNKI)、中国生物医学文献数据库(CBM)和中文科技期刊数据库(CCD)数据库,检索时间为建库至2020年3月,收集关于丹参注射液联合黄芪注射液治疗冠心病心绞痛的随机对照试验,由2位评价员根据疾病的纳入和排除标准提取数据,按照Jadad量表进行质量评价,应用RevMan 5.3软件进行系统评价。结果:最后纳入29个RCT,共2 880例患者。Meta分析结果显示,在总有效率和心电图改善情况方面,合用2种注射液比单用丹参注射液在治疗冠心病心绞痛的效果更佳,差异有统计学意义(OR=4.77,95%CI为3.79~6.00,P<0.000 01;OR=3.96,95%CI为3.14~5.00,P<0.000 01);在心绞痛的改善情况方面,观察组的心绞痛发作频率及连续时间优于对照组;在血液流变学情况方面,部分指标差异有统计学意义;在不良反应方面,差异无统计学意义(OR=1.22,95%CI为0.34~4.35,P=0.76)。结论:本研究结果显示,冠心病心绞痛在西医常规治疗基础上,给予丹参联合黄芪注射液与单用丹参注射液与单纯西医常规治疗比较,其临床疗效、心电图改善情况、心绞痛改善情况及血液流变学改善更加显著。 |
| English Summary: |
| To systematically evaluate the efficacy and safety of Danshen Injection and Huangshen Injection in the treatment of coronary heart disease with angina pectoris.Methods:Computer searched PudMed,Cochrane,CNKI,Wanfang,VIP and CBM database from the establishment of the library to March 2020 to collect randomized controlled trial of Danshen Injection combined with Huangqin Injection in the treatment of coronary heart disease and angina pectoris.A total of 2 reviewers extracted data according to the inclusion and exclusion criteria of the disease.The quality was evaluated according to the Jadad scale,and the RevMan 5.3 software was used for systematic evaluation.Results:A total of 2880 patients in 29 RCTs were included in the study.Meta-analysis showed that in terms of total effective rate and ECG improvement,the combined use of two injections was better than Danshen Injection alone in the treatment of coronary heart disease angina pectoris,and the difference was statistically significant(OR=4.77,95%CI [3.79 to 6.00],P<0.000 01; OR=3.96,95%CI [3.14 to 5.00],P<0.000 01); in terms of the improvement of angina pectoris,the frequency and duration of angina pectoris in the experimental group was superior to that of the control group; In terms of hemorheology,some indicators were statistically different; In terms of adverse reactions,the difference was not statistically significant(OR=1.22,95%CI [0.34 to 4.35],P=0.76).Conclusion:In the treatment of coronary heart disease angina pectoris,in the same case of conventional Western medicine treatment,the clinical efficacy,electrocardiogram improvement,angina pectoris improvement and hemorheology improvement of Danshen combined with Huangqi Injection compared with Danshen injection alone were more significant. |
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