| 引用本文:彭菊琴1，任钧国1，张艺楠2，李春岩3.单核细胞/高密度脂蛋白胆固醇比值与冠心病血瘀证相关性研究[J].世界中医药,2021,(14):. |
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| 单核细胞/高密度脂蛋白胆固醇比值与冠心病血瘀证相关性研究 |
| Relationship Between Monocyte to High-density Lipoprotein Cholesterol Ratio with Blood-Stasis Syndrome in Coronary Heart Disease |
| 投稿时间：2020-09-11 |
| DOI：10.3969/j.issn.1673-7202.2021.14.017 |
| 中文关键词: 冠心病 血瘀证 单核细胞/高密度脂蛋白胆固醇比值 炎症 脂质代谢紊乱 理化指标 诊断 相关性 |
| English Keywords:Coronary heart disease Blood-stasis syndrome Monocyte to high-density lipoprotein cholesterol ratio Inflammation Lipid metabolism disorder Physiochemical index Diagnosis Relationship |
| 基金项目:国家重点研发计划项目(2017YFC1700100);北京市科技计划项目(Z171100001717024) |
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| 中文摘要: |
| 目的:探讨单核细胞/高密度脂蛋白胆固醇比值(MHR)与冠心病血瘀证的相关性。方法:选取2018年1月至2018年7月中日友好医院收治的冠心病患者180例作为研究对象,根据冠心病血瘀证积分分为血瘀证组(n=118)和非血瘀证组(n=62),选取同期非冠心病非血瘀证患者55例作为对照组,比较3组MHR的差异。采用Logistic回归分析MHR与冠心病血瘀证的关系;通过绘制受试者工作特征曲线(ROC),评估MHR诊断冠心病血瘀证的能力。结果:血瘀证组MHR水平高于非血瘀证组和对照组(P<0.01),非血瘀证组和对照组之间MHR水平比较,差异无统计学意义(P>0.05)。Logistic回归分析表明,MHR是冠心病血瘀证的独立危险因素(HR:0.903,95%CI为0.826~0.988,P=0.026)。ROC分析表明,MHR诊断冠心病血瘀证的最佳截止值为14.15,敏感度为83.9%,特异度为68.6%[曲线下面积(AUC)0.609,95%CI为0.521~0.696,P=0.017]。结论:MHR是冠心病血瘀证的独立危险因素,提示脂质驱动的炎症反应可能是冠心病血瘀证形成病理机制之一。 |
| English Summary: |
| To analyze the relationship between monocyte to high-density lipoprotein cholesterol ratio(MHR)with blood-stasis syndrome(BSS)in coronary heart disease(CHD).Methods:A total of 180 CHD inpatients admitted to China-Japan Friendship Hospital from January 2018 to July 2018 were selected as the research objects and were divided into a BSS group(118 cases)and a non-BSS group(62 cases)according to the score of BSS in CHD.A total of 55 participants with non-CHD and non-BSS were recruited as control group.The levels of MHR was compared among 3 groups.Logistic regression was used to analyze the relationship between MHR and BSS score.And receiver operating characteristic(ROC)curve was drawn to evaluate the ability of MHR to diagnose BSS of coronary CHD.Results:The levels of MHR in the BSS group was significantly higher than non-BSS group and control group(P<0.01)，but there were no statistical difference between non-BSS group and control group(P>0.05).Logistic regression analysis showed that MHR was an independent risk factor for BSS in CHD [HR:0.903，95%CI(0.826 to 0.988)，P=0.026].ROC curve analysis demonstrated that the optimal cut-off value of MHR to diagnose BSS in CHD were 14.15，sensitivity of 83.9%，specificity of 68.6% [area under the curve(AUC)0.609，95%CI(0.521 to 0.696); P=0.017].Conclusion:MHR is an independent risk factor for BSS in CHD，which suggests that lipid-driven inflammation may be one of the pathological mechanisms of BSS in CHD. |
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