| 引用本文:刘赛1，李佳豪1，张婴芝1，樊川江1，童应鹏1,2.源于唇形科植物的畲药品种特点分析[J].世界中医药,2021,(15):. |
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| 源于唇形科植物的畲药品种特点分析 |
| Characteristics of She Medicine from Labiatae Plants |
| 投稿时间：2021-06-10 |
| DOI：10.3969/j.issn.1673-7202.2021.15.006 |
| 中文关键词: 唇形科 畲药 药用部位 功效；益母草 网络药理学 糖尿病 |
| English Keywords:Labiatae family She medicine Medicinal parts Efficacy Leonurus japonicus Houttuyn Network pharmacology Diabetes |
| 基金项目:国家重点研发计划项目(2017YFC1703903) |
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| 中文摘要: |
| 目的:分析源于唇形科植物的畲药(简称唇形科畲药)的品种特点,探讨其特殊功效对后期研究的应用价值。方法:通过文献信息分析,获取唇形科畲药的药用部位、多民族交叉使用，尤其是其相对于中药的差异性功效等信息,采用网络药理学的研究方法,对典型中、畲药交叉使用品种作用靶点的相关疾病进行聚类分析和京都基因与基因组百科全书（KEGG）信号通路的富集分析,进而分析畲药差异性功效的科学性。结果:共获得25个唇形科畲药品种,其中19个以全草入药,是最主要的入药部位;与39个少数民族药存在交叉使用情况,其中与土家族、瑶族、苗族、侗族、壮族、彝族等民族药的交叉使用频率较高;受所处生活环境的影响,唇形科畲药主要用于在外感时令病、创伤、妇科病、疮疡病、小儿杂病、瘟疫等。益母草是典型的中、畲药交叉使用品种,畲医认为益母草具有治疗感冒腹痛和产后月内口渴等疾病,与网络药理学的分析结果一致。结论:唇形科畲药具有较高的临床应用价值,尤其是其差异性功效的记载,对后期研究具有较高的借鉴价值;但是其整体研究水平还相对落后,后期还需要进一步加强基于差异性功效的药效学评价、药效物质基础、作用机制和质量控制方法等研究。 |
| English Summary: |
| To analyze the characteristics of She medicines derived from plants in the Labiatae family, and to explore the guiding value of their special effects for later research. Methods:Through the analysis of literature information, the information about the medicinal parts, the cross-use of multiple ethnic groups, especially its different efficacy relative to the Traditional Chinese medicine were obtained, and then the network pharmacology method was used to explore the diseases and KEGG pathways related with typical Chinese-She medicine by cluster and enrichment analysis, respectively, indicating the scientific nature of the differential efficacy of She medicine. Results:A total of 25 She medicine from Labiatae plants were obtained, of which 19 were used as the whole medicinal section. There were cross-uses with 39 ethnic minorities, including Tujia, Yao, Miao, Dong, Zhuang and Yi ethnic groups with a high frequency of cross-use. Due to the living environment, She medicines from Labiatae plants were mainly used for exogenous seasonal diseases, traumatic diseases, female reproductive diseases, sore diseases, pediatric miscellaneous diseases and febrile diseases. Leonurus japonicus Houttuyn was a typical cross-used She medicine. Doctors from She ethnic group believed that Leonurus japonicus can treat colds with abdominal pain and thirst in the postpartum months, which was consistent with the results of network pharmacology. Conclusion:She medicines from Labiatae plants have high clinical application value, especially the records of its differential efficacy, which have high reference value for later research. But its overall research level is still relatively backward, and it needs to be further strengthened in the later research work on pharmacodynamics, material basis and mechanism of She medicine based on its record of differential efficacy. |
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