| 引用本文:赵琦1，王宁2，闫菲1，代恒恒1，王浩浩1，邝浩1，冯隽龙1，邓省1，王世桢1，徐洪胜1，李海松3.人参“异病同治”糖尿病和勃起功能障碍的网络药理学机制探究[J].世界中医药,2021,(15):. |
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| 人参“异病同治”糖尿病和勃起功能障碍的网络药理学机制探究 |
| Research on the Mechanism of Network Pharmacology of Radix Ginseng for “Different Diseases with the Same Treatment” in Diabetes Mellitus and Erectile Dysfunction |
| 投稿时间：2021-03-04 |
| DOI：10.3969/j.issn.1673-7202.2021.15.014 |
| 中文关键词: 网络药理学 人参 糖尿病 勃起功能障碍 异病同治 蛋白质互作 信号通路 血管生成 |
| English Keywords:Network pharmacology Radix Ginseng Diabetes mellitus Erectile dysfunction Treat different diseases with the same treatment Protein-protein interaction Signaling pathway Angiogenesis |
| 基金项目:国家自然科学基金面上项目(81704086)；中华中医药学会青年人才托举工程项目（CACM-2018-QNRC2-C05） |
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| 中文摘要: |
| 目的：运用网络药理学方法预测人参治疗糖尿病和勃起功能障碍的活性成分、作用靶标与关键通路，以探究人参“异病同治”的作用机制。方法：通过检索中医药证候关联数据库（SymMap）、中药系统药理学数据库和分析平台（TCMSP）和中药分子机制的生物信息学分析工具（BATMAN）获取人参所含成分及靶标，结合OMIM、GeneCards疾病数据库分别获取糖尿病和勃起功能障碍2种疾病的共同靶标，将二者取交集得到药物-疾病蛋白质靶标并导入STRING平台进行蛋白质交互网络分析，并通过Cytoscape软件构建网络模块及基因本体（GO）富集分析和京都基因和基因组百科全书（KEGG）通路功能注释。结果：人参治疗糖尿病和勃起功能障碍共病机制与药物应答、缺氧应答、腺苷酸环化酶激活肾上腺素能受体的信号转导途径、血管收缩调节、对尼古丁的反应等生物学功能相关联，主要通过调节cGMP-PKG、核因子κB、HIF-1、TNF等信号通路来实现异病同治的作用。结论：人参治疗糖尿病和勃起功能障碍的共病作用机制主要是通过参与血管生成、促进增殖细胞的迁移和趋化、降低血管内炎症等多途径综合干预，从而发挥单味中药“异病同治”的药效作用。 |
| English Summary: |
| To use network pharmacology methods to predict the active ingredients，targets and key pathways of Radix Ginseng in the treatment of diabetes mellitus and erectile dysfunction，so as to explore the common mechanism of the traditional Chinese medicine“ treating different diseases with the same treatment”Methods:：Through searching SymMap，TCMSP and BATMAN database，we obtained the components and targets of Radix GinsengCombined with OMIM，GeneCards disease database，we obtained the common targets of diabetes mellitus and erectile dysfunction respectivelyWe took the intersection of the 2 to obtain the drug-disease protein target and imported it into the STRING platform for protein interaction network analysis，and used Cytoscape software to construct a network module and GO enrichment analysis and KEGG pathway function annotationResults:The mechanism and biological functions of Radix Ginseng in the treatment of diabetes mellitus and erectile dysfunction were related to drug response，hypoxia response，adenylate cyclase activation of adrenergic receptor signal transduction pathway，vasoconstriction regulation and response to nicotineCorrelation，mainly through the regulation of cGMP-PKG，NF-κB，HIF-1，TNF and other signal pathways to achieve the same treatment of different diseasesConclusion:The mechanism of Radix Ginseng in the treatment of diabetes mellitus and erectile dysfunction is mainly through the participation in angiogenesis，promoting the migration and chemotaxis of proliferating cells，reducing intravascular inflammation and other comprehensive interventions to exert the efficacy of single Chinese medicinal of “different diseases with the same treatment” effect. |
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