| 引用本文:吴静远，许博文，李杰.基于数据挖掘和网络药理学探讨李杰教授中医药巩固治疗乳腺癌经验[J].世界中医药,2021,(15):. |
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| 基于数据挖掘和网络药理学探讨李杰教授中医药巩固治疗乳腺癌经验 |
| Professor LI Jie's Experience on Maintenance Treatment of Breast Cancer with Traditional Chinese Medicine Based on Data Mining and Network Pharmacology Analysis |
| 投稿时间：2020-04-06 |
| DOI：10.3969/j.issn.1673-7202.2021.15.023 |
| 中文关键词: 乳腺癌 网络药理学 中医传承辅助平台 数据挖掘 核心处方 中医药巩固治疗 疏肝健脾 固本清源 |
| English Keywords:Breast cancer Network pharmacology Traditional Chinese medicine inheritance support system Data mining Core prescription Maintenance treatment of breast cancer with traditional Chinese medicine Invigorating the spleen and dispersing the stagnated liver-energy Guben Qingyuan |
| 基金项目:国家自然科学基金项目(81774289)——基于细胞焦亡通路探讨疏肝健脾方调控乳腺癌MDSC-NKT细胞免疫编辑机制研究 |
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| 中文摘要: |
| 目的：挖掘李杰教授中医药巩固治疗乳腺癌临证经验，探讨李杰教授核心处方作用机制。方法：收集李杰教授门诊病例，筛选出连续服中药时间≥3年的乳腺癌术后患者，运用中医传承辅助平台（V25）得到李杰教授临床辨治乳腺癌的高频用药和核心处方，并利用网络药理学方法获取核心处方有效成分、构建网络图和相关作用通路。结果：共有31例患者605首处方纳入研究，得到11味中药组成的核心处方，有效成分与疾病交集靶点166个，富集分析获得相关作用通路43条，构建了蛋白质-蛋白质相互作用（PPI）网络、“中药-成分-靶点”和“靶点-通路”网络图。结论：李杰教授以辨病、辨证、辨症与辨体质时空结合的四位一体观为乳腺癌临床思路，治疗上以“固本清源”、疏肝健脾为指导原则，核心处方主要通过肿瘤的细胞增殖、细胞坏死，激素调节，血管生成与肿瘤微环境，炎症与免疫4个可能方面的多靶点调控起效。 |
| English Summary: |
| To explore Professor LI Jie's clinical experience in the consolidation treatment of breast cancer with traditional Chinese medicine, and to explore Professor LI Jie's core prescription mechanism of action. Methods:We collected the outpatient cases of Prof. LI Jie, and then screened out the postoperative breast cancer patients who have taken Chinese medicinal continuously for ≥ 3 years, used the TCM Inheritance Support System to obtain Professor LI Jie's high-frequency medication and core prescription for clinical treatment of breast cancer, and used the network pharmacology method to obtain the active ingredients of core prescription, constructed the network diagram and related action pathways. Results:A total of 605 prescriptions from 31 patients were included in the study, resulting in a core prescription composed of 11 Chinese medicinal, 166 intersection targets between active ingredients and diseases, 43 related action pathways obtained by enrichment analysis, and PPI, “Chinese medicinal-component-target” and “target-pathway” network maps were constructed. Conclusion:Prof. LI Jie takes the four-in-one combination of disease discrimination, syndrome differentiation, disease discrimination and physical differentiation as the clinical idea of breast cancer. In the treatment,“Guben Qingyuan”and “invigorating the spleen and dispersing the stagnated liver-energy” are taken as the theoretical ideas. The core prescription is mainly through four possible aspects of multi-target regulation:tumor cell proliferation\ cell necrosis, hormone regulation, angiogenesis and tumor microenvironment, inflammation and immunity. |
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