To explore the material basis and mechanism of Qinqi Fengshi Formula(QQFSF) in the treatment of rheumatoid arthritis(RA) based on network pharmacology.Methods:ETCM databases was used to search the components and targets of 3 Chinese medicinals，namely，Panacis Majoris rhizome，Gentianae Macrophyllae Radix，and Corni Fructus in QQFSF.The related targets of RA were retrieved from NCBI and Geencards databases.The target of QQFSF in the treatment of RA was analyzed by PPI network analysis and DAVID for functional pathway enrichment analysis to predict its mechanism of action.The “Chinese medicine-component-target-pathway” network was constructed by Cytoscape 3.7.2 software.Through the topology analysis，the core components and targets were obtained.Results:A total of 122 components in QQFSF were screened，among which 84 components with targets were selected，and 420 targets were screened.A total of 1 225 targets of RA were retrieved.Through mapping analysis，72 common targets of components and diseases were obtained.A total of 1 225 RA targets were retrieved.After mapping analysis，72 common targets of ingredients and diseases were obtained.Through topological analysis of the network，core components such as ursolic acid and oleanolic acid and core components and ABCB1，ABCC1 and PIK3CG and other targets were obtained(P<0.05).After DAVID(P<0.05) enrichment analysis，62 signal pathways were obtained.Finally，the core components and targets were verified by molecular docking technology.Conclusion:The main therapeutic components of QQFSF for RA are ursolic acid，olenolic acid and palmitic acid.The targets mainly involve ABCG2，ABCB1，PIK3CG，etc.，and its therapeutic effect is achieved through thyroid hormone signaling pathway，insulin resistance and NF-κB signaling pathway etc.for the treatment of RA.