To investigate the therapeutic effect of Jiawei Qingxin Lianzi Drink on the curative effects of adriamycin nephrotic syndrome(NS) rats and its effects on proteinuria,blood biochemical indexes and inflammatory factors.Methods:The nephrotic syndrome model of rats was established by injecting adriamycin into tail vein.The rats were given prednisone and modified Jiawei Qingxin Lianzi Drink by gavage respectively,and the control group and model group were set up at the same time.During the experiment,the general morphology of rats was observed,24-hour proteinuria was detected every week.At the end of the experiment,blood was collected to separate serum,and the contents of ALB,TP,TG,TC,BUN and Scr in serum was detected,and the contents of IL-1 β,IL-8,TNF-α and MCP-1 in serum was detected by ELISA.Results:Compared with the control group,the 24 h urine protein content of the model group was significantly different(P<0.01).After administration,the 24 h urine protein content of the hormone group and Chinese medicinal group was significantly reduced(P<0.01).Compared with the blank group,the serum TG,TC,BUN,and Scr levels in the model group were significantly increased(all P<0.01); the serum ALB and TP levels were significantly decreased(P<0.01).After administration,serum TG,TC,BUN,and Scr levels in the hormone group and Chinese medicine group decreased(P<0.01,P<0.05); serum ALB and TP levels increased significantly(all P<0.01).After administration,serum TG,TC,BUN,and Scr levels in the hormone group and Chinese medicinal group decreased(all P<0.01,P<0.05); serum ALB and TP levels increased significantly(all P<0.01).Compared with the control group,the serum levels of IL-1β,IL-8,TNF-α,and MCP-1 in the model group increased(all P<0.05); after administration,the serum IL-1β,IL-8,NF-α,MCP-1 levels in the hormone group and the Chinese medicinal group decreased(all P<0.05).Conclusion:Modified Qingxin Lianzi Drink can treat adriamycin nephrotic syndrome.The mechanism of action is to regulate the expression of inflammatory factors,improve pathological damage,and restore lung,spleen,and kidney functions.