To observe the clinical effect of divergent extracorporeal shock wave treatment of periarthritis of shoulder guided by the theory of meridian tendon.Methods:A total of 67 patients admitted to Beijing No.6 Hospital diagnosed with periarthritis of shoulder and>for 3 months in the Outpatient Department from February 2018 to February 2019 were selected as the research objects.According to random number table method，they were divided into an observation group(n=32) and a control group(n=35).The observation group was treated with divergent shock wave meridian therapy，while the control group was treated with divergent shock wave pain point therapy.Data collection time was that before treatment，after treatment，1 month after treatment，3 months after treatment，and 6 months after treatment.Visual analogue score(VAS) and shoulder function score(CMS) of patients in two groups were recorded.The total response rate was evaluated 6 months after treatment.Results:There was no significant difference between the observation group and the control group in the VAS score after 1 course of treatment and 6 months after treatment(P>0.05).The difference was statistically significant in the comparison of the VAS score between the 2 groups at 1 month after treatment and 3 months after treatment(P<0.05).There was no significant difference in CMS score between the observation group and the control group after one course of treatment(P>0.05)，in other periods after treatment，the difference in CMS scores between the two groups was statistically significant(P<0.05).There was no statistically significant difference in the overall efficacy evaluation of the two groups at 6 months after treatment(P>0.05).Conclusion:Divergent extracorporeal shock wave is an effective method to treat peripheral shoulder diseases.Under the guidance of tendons theory，divergent extracorporeal shock wave treatment of periarthritis of shoulder can effectively shorten the natural course of disease，improve joint function，and have a good long-term effect.