| 引用本文:周嘉培1，王小平1，曹志群2，王永森2.半夏泻心汤治疗功能性消化不良的网络药理学研究[J].世界中医药,2021,(17):. |
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| 半夏泻心汤治疗功能性消化不良的网络药理学研究 |
| Internet Pharmacology Study of Banxia Xiexin Decoction in the Treatment of Functional Dyspepsia |
| 投稿时间：2020-12-16 |
| DOI：10.3969/j.issn.1673-7202.2021.17.010 |
| 中文关键词: 半夏泻心汤 功能性消化不良 作用机制 网络药理学 炎症 胃动力 内脏高敏性 雌激素水平 |
| English Keywords:Banxia Xiexin Decoction Function Dyspepsia Action mechanism Network pharmacology Inflammation Gastric motility Visceral hypersensitivity Estrogen level |
| 基金项目:山东省中医药科技发展计划项目（2019-0186）；山东省名老中医药专家传承工作室建设项目；山东中医药大学首批科研创新团队项目（220316） |
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| 中文摘要: |
| 目的：借助网络药理学平台，研究半夏泻心汤治疗功能性消化不良（FD）的作用靶点及作用机制。方法：基于中药系统药理学数据库与分析平台（TCMSP）筛选半夏泻心汤的有效成分及作用靶点。通过GeneCards数据库提取FD相关基因。运用Cytoscape软件构建“活性成分-靶点-疾病”网络图，上传关键靶点至STRING平台建立蛋白质-蛋白质相互作用网络，最后利用ClueGO插件进行京都基因与基因组百科全书（KEGG）通路富集分析。结果：半夏泻心汤有效活性成分共211种；关键靶点共70个，包括ALB、CASP3、VEGFA等；KEGG通路富集得到相关作用通路15类，主要涉及TNF信号通路、核因子κB信号通路、5-羟色胺（5-HT）信号通路、PI3K-AKT信号通路等。结论：调节炎症、胃动力、胃肠高敏性以及雌激素含量等途径是半夏泻心汤治疗FD的潜在作用机制，本研究为FD治疗方案的进一步改进提供了客观的参考方向。 |
| English Summary: |
| To study the related target and mechanism of Banxia Xiexin Decoction in the treatment of functional dyspepsia by using network pharmacology.Methods:The active ingredients and targets of Banxia Xiexin Decoction were screened by TCMSP.Functional Dyspepsia related genes were extracted from the Genecards database.The network map of “active ingredient-target-disease” was constructed by Cytoscape software.The key targets were uploaded to the STRING platform to establish the protein interaction network.Finally，the ClueGO plug-in was used to analyze the enrichment of the KEGG pathway.Results:There were 211 active ingredients in Banxia Xiexin Decoction; a total of 70 key targets，including ALB，CASP3，VEGFA，EGFE，IL6 and MAPK8.The enrichment of KEGG pathway resulted in 15 types of related pathways，mainly including TNF signaling pathway，NF-kappa B signaling pathway，5-HT signaling pathway and p13k-art signaling pathway.Conclusion:Regulating inflammation，gastric motility，gastrointestinal hypersensitivity，estrogen content and other approaches are the potential mechanisms of Banxia Xiexin Decoction in the treatment of FD.This study provides an objective reference direction for the further improvements of FD treatment. |
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