To investigate the effects of curcumin on the proliferation，migration，invasion and epithelial mesenchymal transformation(EMT) of colorectal cancer cells.Methods:HCT116 cell lines of colorectal cancer were taken and randomly divided into a control group and an intervention group.HCT116 cells in intervention group were treated with curcumin 50 Ug/mL，and HCT116 cells in control group were treated with the same amount of dimethyl sulfoxide.The cell proliferation ability was detected by thiazolium blue(MTT) assay.Cell migration ability was detected by scratch healing assay.Cell invasion ability was detected by Transwell assay.Expression levels of epithelial cadherin(E-cadherin)，neuronal cadherin(N-cadherin)，Vimentin，p-Jagged 1(p-JAG1)，p-Notch receptor 1(p-Notch 1)，and p-Notch receptor 2（p-Notch2) were detected by Western Blotting.Results:Detection of MTT assay showed that curcumin could significantly inhibit the proliferation of HCT116 cells.Wounding healing assay and Transwell assay showed that curcumin could significantly inhibit HCT116 cell migration and invasion.Western Blotting experiments showed that curcumin could increase the expression level of E-cadherin protein，and decrease the expression levels of N-cadherin and Vimentin proteins，as well as p-JAG1，p-Notch1，p-Notch2 and other proteins(P<0.05).Conclusion:Curcumin can significantly inhibit the proliferation，migration，invasion and epithelial mesenchymal transformation of colorectal cancer HCT116 cells，and the mechanism may be related to the inactivation of JAG1/Notch2 pathway.