| 引用本文:余丽金1，许艳1，王莉2，魏丽丽3，肖淑1，李飞飞1.茵栀黄口服液联合西药治疗妊娠期肝内胆汁淤积症患者的临床效果[J].世界中医药,2021,(17):. |
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| 茵栀黄口服液联合西药治疗妊娠期肝内胆汁淤积症患者的临床效果 |
| Clinical Effects of Yinzhihuang Oral Liquid Combined with Western Medicine in the Treatment of Patients with Intrahepatic Cholestasis of Pregnancy |
| 投稿时间：2021-07-05 |
| DOI：10.3969/j.issn.1673-7202.2021.17.018 |
| 中文关键词: 茵栀黄口服液 妊娠期肝内胆汁淤积症 激素 胆汁酸 早产 宫内窘迫 转氨酶 皮肤瘙痒 |
| English Keywords:Yinzhihuang Oral Liquid Intrahepatic cholestasis of pregnancy Hormone Bile acid Premature delivery Intrauterine distress Transaminase Skin pruritus |
| 基金项目:国家自然科学基金项目（81573856） |
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| 中文摘要: |
| 目的：探讨茵栀黄口服液联合西药治疗妊娠期肝内胆汁淤积症患者的临床效果。方法：选取2017年1月至2019年12月海南现代妇女儿童医院收治的妊娠期肝内胆汁淤积症孕妇60例作为研究对象，按照随机数字表法分为对照组和观察组，每组30例。对照组采用西医综合治疗。观察组在对照组用药基础上给予茵栀黄口服液。比较2组患者瘙痒持续时间、黄疸持续时间、胆汁酸（TBA）、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、总胆红素（TBIL）、瘙痒程度评分、母婴结局、不良反应发生率。结果：观察组的治疗效果（100.00%）优于对照组（80.00%）；观察组的瘙痒持续时间、黄疸持续时间短于对照组；2组在治疗后的TBA、ALT、AST、TBIL、瘙痒评分均降低，观察组低于对照组；观察组的产后出血量、早产的比例低于对照组（均P<0.05）。2组的不良反应发生率比较，差异无统计学意义（P>0.05）。结论：针对妊娠期肝内胆汁淤积症的孕妇，在常规使用西药综合治疗的基础上给予茵栀黄口服液，有助于改善各类生化指标，缓解孕妇的瘙痒症状，改善母婴结局，在一定程度上提升疗效，不良反应发生率较低。 |
| English Summary: |
| To investigate the clinical effects of Yinzhihuang Oral Liquid combined with western medicine in the treatment of patients with intrahepatic cholestasis of pregnancy.Methods:From January 2017 to December 2019，a total of 60 pregnant women with intrahepatic cholestasis of pregnancy who were treated in the Obstetrics Department of Hainan Modern Women and Children's Hospital were selected as the research objects.Following random number table method，they were divided into a control group and an observation group，with 30 cases in each group.The control group was treated with comprehensive western medicine.The observation group was given Yinzhihuang Oral Liquid on the medication basis of the control group.The duration of itching，the duration of jaundice，bile acid(TBA)，alanine aminotransferase(ALT)，aspartate aminotransferase(AST)，total bilirubin(TBIL)，and the scores of the itch severity，maternal and infant outcomes，incidence of adverse reactions of the 2 groups were compared.Results:The treatment effects of the observation group(100.00%) was better than that of the control group(80.00%); the duration of pruritus and the duration of jaundice in the observation group were shorter than those of the control group; the TBA，ALT，AST，TBIL and pruritus scores in the 2 groups after treatment were reduced，and the observation group was lower than the control group; the postpartum hemorrhage and the proportion of premature delivery in the observation group were lower than those of the control group(all P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the 2 groups(P>0.05).Conclusion:For pregnant women with intrahepatic cholestasis during pregnancy，Yinzhihuang Oral Liquid is administered on the basis of conventional comprehensive treatment with western medicine，which helps to improve various biochemical indicators，relieve the itching symptoms of pregnant women，and improve maternal and infant outcomes.To a certain extent，the curative effect is improved，and the incidence of adverse reactions is lower. |
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