| 引用本文:龚敏敏，秦鑫，巩静，徐丽君，董慧，陆付耳，赵炎.胡芦巴丸化裁方抗氧化应激改善糖尿病肾病阳虚证的临床研究[J].世界中医药,2021,(19):. |
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| 胡芦巴丸化裁方抗氧化应激改善糖尿病肾病阳虚证的临床研究 |
| Clinical Study of the Amelioration of Modified-Hulubawan on Diabetic Kidney Disease with Deficiency of Kidney Yang through Anti-oxidative Stress |
| 投稿时间：2021-08-10 |
| DOI：10.3969/j.issn.1673-7202.2021.19.004 |
| 中文关键词: 胡芦巴丸化裁方 糖尿病肾病 血糖 尿白蛋白排泄率 氧化应激 |
| English Keywords:Modified-Hulubawan Diabetic kidney disease Blood glucose Urinary albumin excretion rate Oxidative stress |
| 基金项目:国家自然科学基金面上项目（81974567，82174327）；国家中医临床研究基地业务建设第二批科研专项课题（JDZX2015214） |
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| 中文摘要: |
| 目的：探究胡芦巴丸化裁方治疗早期糖尿病肾病（DN）阳虚证的临床疗效，并探索其机制是否与改善氧化应激有关。方法：选取2016年6月至2019年8月华中科技大学同济医学院附属同济医院收治的Ⅲ期DN且中医辨证分型为肾阳虚证患者30例作为研究对象，按照随机数字表法分为对照组和观察组，每组15例。观察组在常规治疗基础上口服胡芦巴丸化裁方，对照组在常规治疗基础上不做另外干预，2组均治疗12周。比较2组血糖、血脂、肝肾功能、临床疗效及血浆抗氧化指标。结果：观察组总有效率为85%，明显高于对照组20%，差异有统计学意义（P<0.05）。治疗前，2组的空腹血糖、糖化血红蛋白比较，差异无统计学意义（P>0.05），2组的血脂、肝肾功能、尿蛋白排泄率（UAER）差异无统计学意义（P>0.05）。超氧化物歧化酶（SOD）和丙二醛（MDA）在治疗前比较，差异无统计学意义（P>0.05）。12周治疗后，2组的空腹血糖、糖化血红蛋白、血脂、肝肾功能比较，差异无统计学意义（P>0.05）。观察组的尿白蛋白排泄率较于对照组明显降低（P<0.05）。观察组的血浆MOD水平低于对照组（P<0.05），而血浆SOD水平显著高于对照组（P<0.05）。在随访过程中无不良反应的发生。结论：胡芦巴丸化裁方治疗早期DN疗效显著，可明显降低患者尿白蛋白排泄率，且安全性高，其机制可能和改善氧化应激有关。 |
| English Summary: |
| To investigate the clinical efficacy of modified-Hulubawan on early diabetic kidney disease(DN) with deficiency of kidney yang,and to explore whether its mechanism is related to improving oxidative stress.Methods:A total of 30 cases of patients diagnosed as stage Ⅲ diabetic kidney disease with deficiency of kidney yang who were admitted to Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology from June 2016 to August 2019 were selected as research objects.They were divided into the control group and modified-Hulubawan treatment group according to the random number table method,15 cases in each group.The treatment group was given additionally oral modified-Hulubawan on the basis of conventional treatment,and the control group have no special intervention besides basic treatment.All the cases were treated for 12 weeks.The blood glucose,blood lipids,liver and kidney functions,clinical effect and plasma antioxidant indexes were compared between the two groups.Results:The total effective rate of modified-Hulubawan treatment group was 85%,which was significantly higher than that of control group(20%),and the difference was statistically significant(P<0.05).Before treatment,there was no statistical significance in the comparison of fasting blood glucose and glycosylated hemoglobin between the two groups(P>0.05),there were also no statistically significant differences in serum lipid,liver and kidney function and urinary albumin excretory rate(UAER) between the two groups(P>0.05).There was no statistically significant difference between superoxide dismutase(SOD) and malondialdehyde(MDA) before treatment(P>0.05).After 12 weeks of treatment,there were no statistically significant differences in FBG,HbA1c,blood lipid,liver and kidney function between the two groups(P>0.05).The urinary albumin excretion rate of the treatment group was significantly lower than that of the control group(P<0.05).The plasma MOD level of treatment group was lower than that of control group(P<0.05),and the plasma SOD level was much higher than that of control group(P<0.05).No adverse events occurred during the follow-up.Conclusion:Modified-hulubawan showed significant efficacy on early diabetic kidney disease and it could sharply reduce urinary albumin excretory rate and it had high safety.The mechanism might be related to improving oxidative stress of diabetic kidney disease. |
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