| 引用本文:任星1，杨静1,2，张菀桐1，高蕊1.基于网络药理学探讨新冠肺炎初期用药清肺排毒汤的作用机制[J].世界中医药,2021,(19):. |
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| 基于网络药理学探讨新冠肺炎初期用药清肺排毒汤的作用机制 |
| Discussion on the Mechanisms of Qinfei Paidu Decoction in the Treatment of Early Stage of COVID-19 Based on Network Pharmacology |
| 投稿时间：2020-12-18 |
| DOI：10.3969/j.issn.1673-7202.2021.19.007 |
| 中文关键词: 清肺排毒汤 网络药理学 新型冠状病毒肺炎 物质基础 作用机制 |
| English Keywords:Qingfei Paidu Decoction Network pharmacology COVID-19 Material basis Action mechanism |
| 基金项目:科技部国家“十三五”支撑计划项目（2017ZX09304003） |
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| 中文摘要: |
| 目的：利用网络药理学方法研究清肺排毒汤（QFPDT）治疗新型冠状病毒肺炎（COVID-19）的物质基础和作用机制。方法:通过中药系统药理学数据库与分析平台（TCMSP）数据库，GeneCards数据库获得药物有效成分、靶点蛋白及相关疾病，运用Uniprot数据库查询靶点蛋白对应的基因名称。借助Cytoscape 3.7.2软件构建药物活性成分-潜在靶点，主要作用靶点-相关疾病的网络模型；运用Cytoscape 3.7.2软件中的ClueGo插件对主要潜在靶点进行基因本体（GO）富集分析和京都基因和基因组百科全书（KEGG）富集分析。结果:经筛选得到278个化合物，177个QFPDT调控的靶点蛋白。根据度(Degree)值得到QFPDT主要有效成分为槲皮素、豆甾醇、β-谷固醇和山柰酚。相关疾病较多的靶点为PTGS2、PPARG、MAPK14和CDK2，与COVID-19相关的疾病包括炎症、哮喘、肺癌、发热、病毒感染等。QFPDT作用的主要通路为IL-17信号通路，雌激素信号通路，血小板活化通路及小细胞肺癌等通路。结论:对QFPDT的物质基础和作用机制进行了初步预测，为QFPDT在COVID-19的临床治疗中提供了依据。 |
| English Summary: |
| To explore the material basis and action mechanism of Qingfei Paidu Decoction(QFPDT) and coronavirus disease(COVID-19) by using network pharmacology.Methods:The active ingredients，target proteins and related diseases were obtained through TCMSP Database.Uniprot database was used to query the gene names corresponding to the target proteins.Cytoscape 3.7.2 software was used to build a network model of drug active ingredients-potential targets and main targets-related diseases; ClueGo plugin of Cytoscape 3.7.2 software was used to perform GO biological processes on main potential targets and KEGG metabolic pathway analysis.Results:After screening，278 compounds and 177 target proteins regulated by QFPDT were obtained.According to the degree value，the main active ingredients of QFPDT were quercetin，stigmasterol，β-sitosterol and kaempferol.The targets of related diseases were PTGS2，PPARG，MAPK14，and CDK2.The diseases related to COVID-19 pneumonia included inflammation，asthma，lung cancer，fever，and viral infection etc.According to the analysis of GO biological processes and KEGG metabolic pathways，the main pathways of QFPDT action were IL-17 signaling pathway，estrogen signaling pathway，platelet activation pathway，and small cell lung cancer.Conclusion:This paper makes a preliminary prediction of the material basis and mechanism of QFPDT，and provided a basis for QFPDT in the clinical treatment of COVID-19. |
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