| The aim of this study was to investigate the mechanism of volatile components of artemisia argyi on knee arthropathy based on network pharmacology.Methods:The volatile component-target network and the disease target network of artemisia argyi were established respectively based on TCMSP,DrugBank and TTD databases.Core targets were enriched by DAVID database for gene ontology(GO) function and genome encyclopedia(KEGG) pathway.Results:The active component-action target network consisted of 40 active components and 265 targets.The annotation analysis of the biological function of the core target obtained by the analysis of the target interaction,the core BP process obtained included steroid metabolism,bile acid and bile salt transport,REDOX,inflammatory response,steroid hormone-mediated signaling pathway,etc.CC process included postsynaptic membrane,protoplasmic membrane composition,plasma membrane,organelle membrane,chlorine channel,etc.The MF process includes heme binding,extracellular ligand gated ion channel activity,steroid hydroxylase activity,iron ion binding,steroid binding,etc.The core KEGG pathways enriched by pathway include the neural ligand receptor interaction pathway,steroid hormone biosynthesis,bile secretion,cytochrome P450 metabolic response to exogenous drugs,negative neural signaling pathway,toll-like receptor signaling pathway,etc.The important active ingredients Predicted were borneol,juniper camphor,isoselanflavin,isoselanol,eugenol,eucalyptus olefine,spartanol,ter-turpentine,-pinene,-borneol acetate,cream-carytene,limonene,cur-elemene and cypreslidene.Conclusion:The effect of volatile components of artemisia argyi on knee arthropathy may be based on the regulation of the neural ligand receptor interaction pathway and the negative conduction of toll-like receptor signaling pathways.The pharmacodynamics may be closely related to borneol,juniper camphor,isoselanthin,isoselanol,eugenol and eucalyptus oil. |
