世界中医药
文章摘要
引用本文:戚媛媛1,韩秀丽2,王旗旗1,杨祺1,王玉明2.基于网络药理学探析补中益气汤治疗变应性鼻炎的作用机制[J].世界中医药,2021,(20):.  
基于网络药理学探析补中益气汤治疗变应性鼻炎的作用机制
Study on the Mechanism of Buzhong Yiqi Decoction in the Treatment of Allergic Rhinitis Based on Network Pharmacology
投稿时间:2020-05-21  
DOI:10.3969/j.issn.1673-7202.2021.20.005
中文关键词:  补中益气汤  变应性鼻炎  网络药理学  药物活性成分  靶点  网络可视化模型  蛋白质-蛋白质相互作用网络  通路富集分析
English Keywords:Buzhong Yiqi Decoction  Allergic Rhinitis  Network Pharmacology  Pharmaceutical Active Ingredients  Target  Network Visualization Model  PPI Network  Pathway Enrichment Analysis
基金项目:山东省中医药管理局齐鲁医派中医学术流派传承项目(2020-008)——齐鲁汪氏耳鼻喉病症中医药特色技术
作者单位
戚媛媛1,韩秀丽2,王旗旗1,杨祺1,王玉明2 1 山东中医药大学济南250011 2 山东省中医院济南250011 
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中文摘要:
      目的:基于网络药理学探析补中益气汤治疗变应性鼻炎的作用机制。方法:通过中药系统药理学数据库与分析平台(TCMSP)筛选得到补中益气汤的化学成分和作用靶点,同时利用GeneCards数据库获得与变应性鼻炎治疗相关的靶基因,利用Cytoscape3.7.1软件将所获得数据进行“药物-成分-疾病-靶点”网络可视化模型构建,使用STRING数据库构建共有靶基因的蛋白质-蛋白质相互作用( PPI)网络,最后采用R软件以P<0.05、Q<0.05进行关键靶基因本体(GO)富集分析和京都基因和基因组百科全书(KEGG) 功能富集分析。结果:筛选出补中益气汤有效活性成分172个,其治疗变应性鼻炎的机制可能与IL6、VEGFA、JUN、MMP9、MMP2等核心靶蛋白密切相关,推测其主要通过参与IL-17、TNF、HIF-1、Toll样受体、PI3K-AKT、核因子κB、MAPK、Th1和Th2细胞分化、JAK-STAT等信号通路干预调控变应性鼻炎。结论:本研究揭示了补中益气汤治疗变应性鼻炎多基因、多靶点、多通路的网络调节机制,从整体角度阐述了中医药有效的作用机制,为下一步实验研究提供分子层面的思路。
English Summary:
      To study the mechanism of Buzhong Yiqi Decoction in the treatment of allergic rhinitis based on network pharmacology.Methods:The chemical components and targets of Buzhong Yiqi Decoction were screened according to the traditional Chinese medicine system pharmacology database and analysis platform(TCMSP) database platform.Meanwhile,gene card database was used to obtain the target genes related to the treatment of allergic rhinitis.The network visualization model of drugs,components,diseases and targets was built by using the software of Cytoscape 3.7.1.The PPI network of protein interaction of common target genes was constructed by using STRING database.Finally,the function enrichment analysis of key target genes GO and KEGG was carried out by using R software(P<0.05) Q<0.05 was for functional enrichment analysis of key target genes GO and KEGG.Results:A total of 172 active components of Buzhongyiqi Decoction were screened out.The mechanism of its treatment of allergic rhinitis may be closely related to IL6,VEGFA,JUN,MMP9,MMP2 and other core targets.It is speculated that it mainly participated in the regulation of allergic rhinitis through signal pathways such as IL-17,TNF,HIF-1,Toll like receptor,PI3K-AKT,NF-κB,MAPK,Th1 and Th2 cell differentiation,JAK-STAT etc.Conclusion:This study reveals the network regulation mechanism of Buzhong Yiqi Decoction in the treatment of allergic rhinitis,and explains the effective mechanism of TCM from a holistic perspective,and provide molecular thinking for the next step of experimental research.
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