To predict the main active components,targets and signal pathways of Radix Salviae Miltiorrhizae in the treatment of chronic hepatitis and to explore the mechanism of action.Methods:The effective components of Radix Salviae Miltiorrhizae were screened by TCMSP database.The corresponding genes were obtained by entering Pharm Mapper database.The target genes of chronic hepatitis were obtained by searching GeneCards database.We used R language 3.6.3 intercept intersection network to obtain candidate targets; With the help of Cytoscape 3.7.2,the network of “drug-compound-target-disease” was visualized.We built PPI network on STRING platform; the DAVID database was used for GO enrichment analysis and KEGG pathway annotation of the candidate targets.Results:A total of 65 effective compounds,109 non-repeated targets and 89 disease treatment targets were obtained.There were 48 GO items(P<0.05),among which 1796 were biological process(BP) items,73 were cell components(CC) items,and 130 were molecular function(MF) items.There were 88 signal pathways enriched by KEGG pathway(P<0.05).Conclusion:The effective ingredients of Radix Salviae Miltiorrhizae Isocryptotanshi-none,1,2,5,6-tetrahydrotanshinone,miltionone I,dihydrotanshinlactone,4-methylenemiltirone,Tanshinone IIa,Luteolin may act on key targets such as ADRB2,OPRM1,PTGS1,CA2,and PTGS2 by regulating Hepatitis B,IL-17 signaling pathway,Hepatitis C,T cell receptor signaling pathway,PI3K-AKT signaling pathway,etc.,intervening in the process of reactive oxygen metabolism,circulatory system vascular function,oxidative stress response,apoptosis,and thus play a role in the treatment of chronic hepatitis.