To explore the effect and mechanism of nano-components in distilled egg yolk in the treatment of eczema.Methods:Distillate egg yolk was extracted with water to obtain an aqueous solution of distilled egg yolk(EYO-CDs) rich in nano-components.A mouse model of chronic eczema was established with 2,4-dinitrochlorobenzene alcohol solution,and the compound dexamethasone acetate cream was used as a positive control to evaluate the action and mechanism of EYO-CDs in the treatment of eczema.Results:EYO-CDs can reduce ear swelling in mice with chronic eczema,reduce interleukin-4(IL-4),interleukin-17(IL-17) and increase interferon-γ(INF-γ) in serum and tissues.The results of HE staining showed that pathological phenomena such as epidermal keratosis,edema,lymphocyte infiltration,dermal vasodilation and congestion in ear tissues were relieved to varying degrees after administration.The therapeutic effect has a certain dose-effect relationship with the administration concentration.Conclusion:EYO-CDs in distilled egg yolk has a therapeutic effect on chronic eczema in mice,mainly by inhibiting inflammatory factors and regulating immune factors,providing experimental evidence for clinical application.