To evaluate the efficacy and safety of the combination of Rhizoma Polygonati and Notoginseng compatibility in the treatment of coronary heart disease angina pectoris.Methods:CNKI,CBM,CCD,CSPD,Cochrane Library,Pubmed,EMBASE were electrically searched.The treatment group used traditional Chinese medicine combined with conventional Western medicine to treat coronary heart disease angina pectoris,and the control group used conventional Western medicine for randomized controlled study.The traditional Chinese medicinal intervention prescription groups took Rhizoma polygonati and panax notoginseng as the essential medicines for invigorating qi and activating blood circulation.We evaluated the quality of literature according to relevant methods,and extracted the literature data.RevMan 5.3 software was used for Meta analysis.Results:A total of 1 238 patients were enrolled in 13 studies.Compared with the control group,the treatment group can significantly improve the clinical efficacy(P<0.000 01); it can significantly improve electrocardiogram efficacy(P<0.000 01); it can significantly reduce the frequency of angina attacks(P=0.000 5); It can significantly reduce LDL levels(P<0.000 01); it can significantly increase HDL levels(P<0.000 01); it can significantly reduce total cholesterol levels(P<0.000 01); it can significantly reduce triglyceride levels(P<0.000 01); it can significantly increase the level of nitric oxide(P=0.002); it can significantly reduce the level of endothelin(P=0.000 3); Conclusion:Rhizoma Polygonati and Notoginseng are effective drugs for clinical treatment of coronary heart disease angina pectoris.