Couplet medicinals are one of the important characteristics of traditional Chinese medicine(TCM) in the treatment of tumor.Because of its delicate composition,flexible addition and subtraction,it can also be used as an independent prescription,highlighting the thinking of the special prescription of TCM.Professor LI Jie's characteristics of diagnosis and treatment are “first differentiating diseases,then differentiating syndrome,assisting with differentiating symptom,three in one”.On the basis of the combination of diseases,according to the difference of individualized diseases,the effective use of couplet medicinals for the treatment of common tumors has a significant clinical effect.In this paper,Professor LI Jie's commonly used couplet medicinals in the treatment of tumor are summarized,in order to improve the clinical efficacy and guide clinical application.The empirical application and condensation of couplet medicinals have certain promoting significance for the research and development of new drugs of traditional Chinese medicine.