Based on network pharmacology,the action mechanism of Ganmai Dazao Decoction was investigated.Methods:The active ingredients and targets of Radix Glycyrrhizae,wheat and Fructus Jujubae were obtained by using the Traditional Chinese Medicine System Pharmacology Database and Analysis Platform (TCMSP),the Chinese Medicine Molecular Mechanism Bioinformatics Analysis Tool Library (BATMAN-TCM) and the literature search.From the GeneCards database we obtained depression targets and drug disease intersection targets,constructed a protein-protein interaction (PPI) network through the String online platform database,and used Cytoscape software for visualization and topological analysis to screen core genes,and used the DAVID database to complete the gene ontology (GO) function and enrichment analysis of Kyoto Encyclopedia of Genes and Genome (KEGG) pathway.Results:A total of 94 active ingredients of Chinese medicinal,49 effective targets,and 48 drug disease intersection targets were screened out.PPI network found that ALB,CASP3,VEGFA,MYC,CCND1,ESR1,CTNNB1,AR,etc.may be key targets.GO functional enrichment analysis revealed 181 biological processes,mainly involving estrogen response and cholinergic synaptic transmission.KEGG pathway enrichment analysis found 46 pathways,mainly focusing on cancer-related pathways,thyroid hormone signaling pathway,PI3K-AKT signaling pathway,Wnt signaling pathway,etc.Conclusion:This study provides a theoretical basis for further research on the effective material basis of Ganmai Dazao Decoction,and at the same time provides a reference basis for its application in antidepressant.