To study the effect of Jianpi Zhidong Decoction on the expression of cytokines in peripheral blood，colon，cortex and striatum of Tourette Syndrome (TS) model rats.Methods:The TS animal model was established by intraperitoneal injection of iminodipropionitrile (IDPN) and the rates was randomly divided into a blank control group，a model group，a Tiapride group，and a Jianpi Zhidong Decoction group.The model group and the blank control group were given 0.9% normal saline by gavage.The other 2 groups were given equal volumes of Tiapride suspension and Jianpi Zhidongtang Granule solution for 6 weeks.After the administration，enzyme-linked immunosorbent assay (ELISA) was used to detect IL-1，IL-2，IL-4，IL-6，IL-10，INF-γ，TNF-α and colon，The expression levels of INF-γ and TNF-α in the cortex and striatum.Results:1) The expressions of IL-1，IL-2，IL-6，IFN-γ，and TNF-α in the Jianpi Zhidong Decoction group were significantly lower than those in the model group (P<0.05) and Tiapride group (P<0.05); 2 ) The expression of INF-γ and TNF-α in Jianpi Zhidong Decoction group was significantly lower than that of model group (P<0.05) and Tiapride group (P<0.05); 3) INF-γ and TNF-The expression of α was significantly lower than that of the model group (P<0.05) and the Tiapride group (P<0.05).The INF-γ and TNF-α expressions of the Tiapride group had no significant changes compared with the model group (P>0.05).Conclusion:IDPN-induced TS model has immune dysfunction.Jianpi Zhidong Decoction can inhibit the release of various pro-inflammatory factors in peripheral and central tissues，and its anti-inflammatory effect may have a certain auxiliary regulatory effect in controlling the onset of TS.