The pharmaceutical process of Chinese medicinal is complex,and the level of process control is directly related to product quality.Carrying out research on the quality evaluation and quality control of the pharmaceutical process and improving the understanding of the pharmaceutical process are of great significance to ensure the safety and effectiveness of Chinese medicinal preparations.With the development of nuclear magnetic resonance technology,hydrogen nuclear magnetic resonance spectroscopy has been widely used in the fields of quality evaluation of Chinese medicinal and metabolomics research.This paper mainly introduces the application progress of proton nuclear magnetic resonance omics technology in the research of Chinese medicinal processing,extraction and other pharmaceutical processes,identifying process chemical markers,studying the transformation and transfer law of metabolites in the process,etc.The application prospect of process omics research of proton nuclear magnetic resonance (1H NMR) in the field of traditional Chinese medicine and pharmaceuticals.