To study the mechanism of“Yiqi Zhuyu Decoction” in the treatment of advanced gastric cancer based on network pharmacology and molecular docking.Methods:Through the TCM System Pharmacology Database and Analysis Platform (TCMSP) and the Encyclopedia of Traditional Chinese Medicine Database (ETCM),we obtained the relevant targets of the chemical composition and action of all medicines of Yiqi Zhuyu Decoction,and screened out the targets of gastric cancer through GeneCards,OMIM,and GEO databases Point,by using the R language to take the intersection for Venn analysis,imported the obtained target into Cytoscape 3.7.2 software,constructed the active ingredient target network,and imported it into the String database to construct the protein-protein interaction (PPI) network.And we used the Bisogenet plug-in in Cytoscape 3.7.2 to analyze the network topology.At the same time,we used the R language Bioconductor platform to perform GO analysis and KEGG analysis on the potential targets of Yiqi Zhuyu Decoction in the treatment of gastric cancer,and import the results into Cytoscape 3.7.2 software for drawing,and obtained the KEGG network relationship diagram.We used the molecular docking software Autodock vina to dock the core target with the active ingredient,and finally draw the picture with Plmoy.Results:A total of 216 chemical components and 1 105 disease targets were obtained,of which 38 were intersection targets.The key targets include IL-6,MMP9,PTGS2.GO function analysis was mainly related to the expression of lipopolysaccharide,oxidase reduction activity and so on.KEGG analysis showed that Yiqi Zhuyu Decoction treats gastric cancer mainly through IL-17,TNF,nuclear factor-κB,TLR and cancer-related signal pathways.The molecular docking results showed the best binding performance with MMP9.Conclusion:Yiqi Zhuyu Decoction treats gastric cancer through multiple components and multiple targets,laying a foundation for further research on its mechanism of action.