稳定期慢性阻塞性肺疾病患者中医体质分布规律研究
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国家自然科学基金项目(81660739,81973605)


Relationship Between the Stable COPD and the Traditional Chinese Medicine Syndromes:A Meta-Analysis
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    摘要:

    目的:系统评价稳定期慢性阻塞性肺疾病中医体质的分布状况,为慢性阻塞性肺疾病的中医药防治提供循证依据。方法:从中国期刊全文数据库、中国学术期刊数据库、中文科技期刊数据库、Pubmed等4个中英文数据库,2名研究者独立进行相关文献的检索、筛选及信息提取工作。运用Stata13.0软件对纳入的研究合并效应量进行荟萃分析,采用亚组分析、敏感性分析探求较大异质性的可能来源,最后应用Begg、Egger方法检测发表偏倚。结果:最终纳入17项横断面研究,共计5 077例患者。方法学质量评价中高质量和低质量研究各2项,中等质量研究13项。稳定期COPD患者中医体质类型的比例和95%置信区间从高到低排列前5位依次为气虚质28%(95%CI为24%~32%)、阳虚质21%(95%CI为17%~25%)、痰湿质14%(95%CI为11%~18%)、阴虚质10%(95%CI为7%~13%)、湿热质8%(95%CI为6%~10%)。此外稳定期慢阻肺中医体质分布在性别、地区等方面具有差异。Begg、Egger检测发现并未存在明显发表偏倚。结论:气虚质、阳虚质、痰湿质、阴虚质是稳定期慢阻肺的主要偏颇体质类型,且部分中医体质在性别、地区等方面存在差异。建议今后相关研究应遵循横断面研究的循证医学规范,以提高研究质量。

    Abstract:

    To systematically evaluate the distribution of traditional Chinese Medicine (TCM) constitutions in stable chronic obstructive pulmonary disease (COPD),and to provide evidence-based evidence for the prevention and treatment of COPD by TCM.Methods:A total of 4 Chinese and English databases,including CNKI,WAN FANG,VIP,and Pubmed,were searched by computer using a comprehensive retrieval strategy.A total of 2 researchers independently searched,screened,and extracted the literature on the correlation between TCM constitution and chronic obstructive pulmonary disease worldwide.Stata13.0 software was used to conduct a meta-analysis on the combined effect sizes of included studies,and subgroup analysis and sensitivity analysis were used to explore possible sources of greater heterogeneity.Finally,Begg,Egger methods were used to detect publication bias.Results:After strict inclusion and exclusion criteria,17 cross-sectional studies were included,with a total of 5,077 patients.AHRG evaluation criteria were used to evaluate the methodological quality of the included studies,including two high quality and two low-quality studies,and 13 medium quality studies.The proportion and 95% confidence interval of TCM constitution types in stable COPD patients were qi-deficiency 28%[95%CI(24%,32%)],yang-deficiency 21%[95%CI(17%,25%)],phlegm-dampness 14%[95%CI(11%,18%)],yin-deficiency 10%[95%CI(7%,13%)],and damp-heat constitution 8%[95%CI(6%,10%)].Besides,there are differences in the distribution of TCM constitutions of COPD by gender and region.The findings of Begg's,Egger's showed no significant publication bias.Conclusion:Qi-deficiency,yang-deficiency,phlegm-dampness,and yin-deficiency are the main types of biased constitutions in COPD at a stable period,and some TCM constitutions are different in gender and region.To improve the quality of literature,it is suggested that the related research should follow the EBM standard of a cross-sectional study.

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王益德,李争,李风森.稳定期慢性阻塞性肺疾病患者中医体质分布规律研究[J].世界中医药,2021,(23).

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  • 收稿日期:2020-07-01
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  • 在线发布日期: 2022-01-05
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