To study the mechanism of total glucosides of paeony(TGP) on lung tissue of rats with lung cancer.Methods:The rats were divided into a normal group，a model group and a total paeony glycosides group.The body mass changes of the 3 groups were observed.The lung index and lung tissue morphology changes of the three groups were compared，and the survivin in the lung tissue of the rats was compared(Survivin)，Kirsten rat sarcoma viral oncogene(KRAS) expression and mRNA expression.Results:There was no significant difference in the weight of the 3 groups at the same time(P<0.05).Compared with the three groups of rats，the weight gain of TGP group was significantly higher than that of model group，and the final weight of TGP group was also significantly heavier than that of model group(P<0.05).Compared with the normal group，the lung index of the model group increased significantly(P<0.05)，and the lung tissue deteriorated significantly; compared with the model group，the lung index of the TGP group decreased significantly(P<0.05)，and the lung tissue improved significantly(P<0.05).The positive expression of Survivin and KRAS in the model group was significantly increased in the three groups，and the mRNA expression in the group was significantly higher than that in the normal group(P<0.05); the positive expression and mRNA expression in the TGP group were significantly lower than that in the model group(P<0.05).Conclusion:TGP can effectively inhibit the expression of Survivin and KRAS genes in lung tissue of lung cancer rats，and inhibit the angiogenesis.