To study the protective effects of curcumin combined with atorvastatin on ulcerative colitis(UC) in mice and its underlying mechanisms.Methods:The mice were randomly divided into a control group，a model group，a curcumin group，an atorvastatin group and a combination group，with eight mice in each group.Except for the control mice，the other mice used the 5% DSS-induced ulcerative colitis mouse model.On the first day of modeling，rats were intragastrically administered with curcumin 60 mg/kg suspension and atorvastatin 10 mg/kg suspension，respectively.The rats in the combination group were intragastrically administered with 60 mg/kg curcumin suspension and 10 mg/kg atorvastatin suspension，and the mice in the control group and model group were intragastrically administered with normal saline once daily，1 mL each time，for 7 consecutive days.The DAI score of each group was observed and recorded，and the colon length was compared.The levels of inflammatory factors and oxidative stress were detected by ELISA.The autophagosomes in colonic tissues were observed by transmission electron microscopy.The expression of autophagy-related proteins was detected by WB experiment.Results:Compared with the model group and the medication group alone，the DAI score of the mice in the combination group was significantly reduced，and the colon length was significantly increased.The contents of serum TNF-α，IL-1β and IL-6 were significantly reduced，while the content of IL-10 was significantly increased.The levels of MPO and MDA in the colon tissue were significantly decreased，while the levels of SOD and GSH-Px were significantly increased.The number of autophagosomes increased，the expression level of p62 protein was significantly reduced，and the protein levels of Beclin1 and LC3Ⅱ/LC3Ⅰ were significantly increased(Ps<0.05).Conclusion:Curcumin combined with atorvastatin can control the level of oxidative stress by regulating the expression of autophagy-related proteins，so as to have a therapeutic and protective effect on ulcerative colitis mice.