To investigate whether the use of deer and melon polypeptide injection in patients with fractures in the real world might affect their renal function.Methods:In the hospital information system(HIS) database of 26 first-class hospitals in China，a total of 12 847 fracture patients(lugua group) and 12 619 fracture patients(control group) without lugua polypeptide injection were selected for the study.Weight method of GBM tendency score was used to control confounding factors，and logistic comparison was conducted to analyze whether there were statistical differences in renal dysfunction between the two groups in the real world.Results:Logistic analysis was used to analyze the differences of abnormal results of renal function(Cr and BUN) in the 2 groups，and the(P>0.5).The differences of abnormal renal function(Cr and BUN) results between the 2 Logistic groups after weighted by the propensity score(P>0.5).Conclusion:according to the current data and analysis methods，it is believed that deer melon polypeptide and osteopeptide injection may not cause abnormal renal function(Cr and BUN) in patients.