苍附导痰汤治疗多囊卵巢综合征胰岛素抵抗的作用机制
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黑龙江省自然科学基金项目(LH2019H116);黑龙江省中医药管理局科研项目(ZHY18-073)


Analysis on Mechanism of Cangfu Daotan Decoction on Insulin Resistance in Polycystic Ovary Syndrome
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    摘要:

    多囊卵巢综合征(PCOS)主要是一种以生殖功能异常以及糖代谢紊乱为主要表现的妇科内分泌常见疾病。且有50%~70%的PCOS患者伴有胰岛素抵抗,而胰岛素抵抗亦是导致PCOS月经异常、排卵障碍、不孕、子宫内膜病变的重要因素。下丘脑-垂体-卵巢-子宫各靶器官的胰岛素抵抗均参与了PCOS病理机制的形成。西医对该病的治疗虽在短期有一定的效果,但后遗症较多,复发率高。中医学认为PCOS胰岛素抵抗的形成与痰湿瘀滞的病理因素密切相关。临床以化痰祛湿的代表方剂苍附导痰汤治疗PCOS胰岛素抵抗有明确的疗效,且不良反应低。现通过对苍附导痰汤治疗PCOS胰岛素抵抗的作用机制进行分析阐述,目的在于为化痰祛湿代表方剂苍附导痰汤应用于临床PCOS胰岛素抵抗的治疗提供理论依据。

    Abstract:

    Polycystic ovary syndrome(PCOS) is a common gynecological endocrine disease characterized by abnormal reproductive function and glucose metabolism.In addition,50%~70% of PCOS patients are accompanied by insulin resistance,which is also an important factor leading to menstrual abnormalities,ovulation disorders,infertility and endometrial lesions.Insulin resistance in the target organs of hypothalamus pituitary ovary uterus is involved in the formation of PCOS pathological constitution.Although Western medicine has a certain effect on the treatment of the disease in the short term,there are many sequelae and high recurrence rate.Traditional Chinese medicine believes that the formation of PCOS insulin resistance is closely related to the pathological factors of phlegm dampness and stasis.Cangfu Daotan Decoction,a representative prescription of resolving phlegm and removing dampness,has a definite therapeutic effect on insulin resistance of PCOS with low side effects.In this paper,the mechanism of Cangfu Daotan Decoction in the treatment of PCOS insulin resistance was described and analyzed,in order to provide a theoretical basis for the application of Cangfu Daotan Decoction in the treatment of PCOS insulin resistance.

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张多加,吴效科.苍附导痰汤治疗多囊卵巢综合征胰岛素抵抗的作用机制[J].世界中医药,2022,(02).

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  • 收稿日期:2020-05-16
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  • 在线发布日期: 2022-02-14
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