To explore the mechanism of Lycii Fructus in the treatment of Alzheimer's disease (AD) based on network pharmacology and molecular docking.Methods:The targets of Lycii Fructus against AD were screened out from TCMSP，GeneCards，NCBI，and OMIM by network pharmacology.The Venn diagram was plotted to obtain the common targets of Lycii Fructus and AD.The protein-protein interaction (PPI) network was delineated by STRING.Cytoscape 3.8.0 was used for visualization processing，and key genes were screened out.The common targets of Lycii Fructus and AD underwent GO and KEGG pathway enrichment analyses.AutoDock Tools 1.5.6 was used for molecular docking to verify the binding degree between the targets and small molecules.Results:A total of 121 common targets and 41 key targets of Lycii Fructus and AD were obtained，including JUN，AKT1，MAPK1，RELA，and IL-6.As revealed by GO analysis，oxidative stress，aging，and other biological processes were mainly involved.KEGG pathway analysis showed that the pathways were mainly enriched in AGE-RAGE，HIF-1，and other signaling pathways.MAPK1 had good binding activity with β-sitosterol as indicated by molecular docking.Conclusion:The present study investigated the main active components，related targets，and related pathways of Lycii Fructus in the treatment of AD，and unraveled the characteristics of multi-component，multi-target，and multi-pathway，which provided references and material basis for the follow-up experimental verification.