| 引用本文:覃凤飞,郭东霖,邱汉波,凌慧,李洲强,侯恩存.柴胡加龙骨牡蛎汤治疗肿瘤相关抑郁症的Meta分析[J].世界中医药,2022,(03):. |
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| 柴胡加龙骨牡蛎汤治疗肿瘤相关抑郁症的Meta分析 |
| Meta-analysis of Radix Bupleuri plus Longgu Muli Decoction in the Treatment of Tumor-related Depression |
| 投稿时间：2020-04-23 |
| DOI：10.3969/j.issn.1673-7202.2022.03.016 |
| 中文关键词: 柴胡加龙骨牡蛎汤 恶性肿瘤 癌 抑郁症 Meta分析 汉密尔顿抑郁量表评分 总有效率 不良反应 生命质量 |
| English Keywords:Radix Bupleuri plus Longgu Muli Decoction Malignant neoplasm Cancer Depression Meta-analysis Hamilton Depression Scale score Total effective rate Adverse reactions Quality of life |
| 基金项目:北京医卫健康公益基金会项目（YWJKJJHKYJJ-F3208D） |
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| 中文摘要: |
| 目的：对柴胡加龙骨牡蛎汤治疗肿瘤相关抑郁症的情况进行Meta分析，以期了解柴胡加龙骨牡蛎汤的临床疗效及安全性等。方法：收集已公开发表的有关柴胡加龙骨牡蛎汤治疗肿瘤相关抑郁症的临床随机对照试验，采用RevMan5.3对符合条件的研究进行Meta分析，评价柴胡加龙骨牡蛎汤治疗肿瘤相关抑郁症的临床疗效及安全性。结果：符合纳入标准文献共15篇，总样本量1 568例。观察组与对照组比较，汉密顿抑郁量表（HAMD）评分减低更明显，差异有统计学意义（MD=-5.11，95%CI为-7.39～-2.83，P<0.000 01）；不良反应的发生更少，差异有统计学意义（RR=0.21，95%CI为0.11～0.41，P<0.000 01）；总有效率更高，差异有统计学意义（RR=1.14，95%CI为1.07～1.22，P=0.000 1）；生命质量评分提高更明显，差异有统计学意义（RR=0.21，95%CI为0.11～0.41，P<0.000 01）。结论：柴胡加龙骨牡蛎汤具有显著的抗肿瘤相关抑抑郁症作用，及相比传统抗抑郁西药有其独特的优势。 |
| English Summary: |
| To conduct a meta-analysis on the treatment of tumor-related depression with Radix Bupleuri plus Longgu Muli Decoction，in order to understand the clinical efficacy and safety of such treatment.Methods:Published randomized controlled clinical trials(RCTs)of Radix Bupleuri plus Longgu Muli Decoction in the treatment of tumor-related depression were collected，and the eligible studies were meta-analyzed with RevMan5.3 to evaluate the clinical efficacy and safety of Radix Bupleuri plus Longgu Muli Decoction in the treatment of tumor-related depression.Results:A total of 15 studies met eligibility criteria and was included，with a total sample size of 1 568.Compared with the control group，the reduction of HAMD score in the experimental group was more significantly lower，and the difference was statistically significant [MD=-5.11，95%CI(-7.39 to -2.83)，P<0.000 01].Adverse reactions were less frequent and the difference was statistically significant [RR=0.21，95%CI(0.11 to 0.41)，P<0.000 01].The total effective rate was higher and the difference was statistically significant [RR=1.14，95%CI(1.07 to 1.22)，P=0.000 1].The improvement in quality of life score was even more significant，with a statistically significant difference [RR=0.21，95%CI(0.11 to 0.41)，P<0.000 01].Conclusion:Radix Bupleuri plus Longgu Muli Decoction has significant effects on tumor-related depression and has its unique advantages compared with western anti-depression drugs. |
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