| 引用本文:杨亚男1,李艳杰2,陈玉鹏2,倪青1.已上市中成药治疗糖尿病的用药规律及核心处方挖掘[J].世界中医药,2022,(03):. |
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| 已上市中成药治疗糖尿病的用药规律及核心处方挖掘 |
| Medication Regularity and Core Prescriptions of Marketed Chinese Patent Medicines Against Diabetes |
| 投稿时间：2021-04-14 |
| DOI：10.3969/j.issn.1673-7202.2022.03.022 |
| 中文关键词: 糖尿病 中成药 复杂网络 关联规则 用药规律 配伍 核心处方 数据挖掘 |
| English Keywords:Diabetes Chinese patent medicine Complex networks Association rule Medication regularity Compatibility of drugs Core prescription Data mining |
| 基金项目:北京市自然科学基金项目（7182143） |
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| 中文摘要: |
| 目的：通过数据挖掘研究已上市中成药治疗糖尿病的用药规律及核心处方，为临床更好地治疗糖尿病和新药研发提供新思路。方法：从2020版《中华人民共和国药典》及药智网“中成药处方数据库”中查找“消渴”“糖尿病”等关键词，找出治疗糖尿病的中成药处方并建立数据库，通过Excel、中医医案知识服务共享系统、复杂网络分析软件（Liquorice软件）对所涉及中药进行归纳分析。结果：共纳入中成药71种，涉及中药158味，得出了这些药物的用药频次、性味归经特征及组方规律；得到71种中成药的核心处方；主要证型为气阴两虚证、气阴两虚兼内热、阴虚内热、气阴两虚兼血瘀、阴虚燥热兼气虚血瘀证，并分别得到5个证型的核心处方及相应配伍。结论：通过运用数理统计方法对已上市治疗糖尿病的中成药进行组方分析，得出其用药规律及和核心处方，可为指导临床用药及新药研发提供参考。 |
| English Summary: |
| To investigate the medication regularity and core prescriptions of marketed Chinese patent medicines against diabetes by data mining in order to provide references for clinical treatment of diabetes and new ideas for new drug development.Methods:The Chinese Pharmacopoeia (2020) and Yaozh.com were searched for prescriptions of Chinese patent medicine against diabetes with key terms of “consumptive thirst” and “diabetes” and the database was established.Crude drugs involved were summarized and analyzed through Excel，TCM Knowledge Service and Sharing System，and Liquorice.Results:Seventy-one Chinese patent medicines were included，involving 158 crude drugs.The frequency of use，properties (nature，flavor，and meridian tropism)，and compatibility of these drugs were obtained.The core prescriptions of 71 crude drugs were screened out by complex network analysis.As revealed by syndrome classification of included prescriptions，the main syndromes included qi-yin deficiency，qi-yin deficiency and internal heat，yin deficiency and internal heat，qi-yin deficiency and blood stasis，and yin deficiency-generated internal heat combined with qi deficiency and blood stasis，and the corresponding core prescriptions were obtained.Conclusion:Through the analysis of prescriptions of Chinese patent medicines marketed for the treatment of diabetes by mathematical statistics methods，the medication regularity and core prescriptions can be obtained，which can provide ideas for clinical medication and the development of new drugs． |
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