Infantile asthma syndrome is common in clinical practice，which is most closely related to lung，and also to heart，liver，spleen，and kidney.Based on the physiological characteristics of “deficiencies in spleen，lung，and kidney and excess in heart and liver” in children，the present study explored the etiology，pathogenesis，and treatment of infantile asthma syndrome in children in combination with modern pathogenesis，and discussed the characteristics and symptoms of infantile asthma syndrome in children exemplified with diseases such as bronchial asthma，bronchiolitis obliterans，and gastroesophageal reflux disease to provide new ideas for the treatment of asthma syndrome for later generations.