Real-world research is the hot spot and the main trend of clinical research in Chinese medicine and the key to real-world research is the processing of real-world data.The top priority in data processing is the multi-source heterogeneous data integration.However，no systematic study on multi-source heterogeneous data integration in real-world research in Chinese medicine is available.Therefore，based on literature analysis，this paper summarized the basic characteristics of real-world data in Chinese medicine，the key techniques for multi-source heterogeneous data integration，and the application of integrated data to real-world research.Moreover，this paper described how the techniques and methods for multi-source heterogeneous data integration can be applied to real-world research in Chinese medicine，compared the workflow of data integration based on database research，foresaw how to use the technology to further highlight the characteristics of clinical data in Chinese medicine，break the bottleneck of real-world research in Chinese medicine，and resolve related problems，and discussed the challenges in both the infrastructure and implementation.