This study aims to analyze the point selection pattern for acupuncture treatment of autism spectrum disorder(ASD) based on data mining of clinical medical records，which is expected to provide a reference for optimizing the clinical treatment plan.Methods:The data on acupuncture treatment in the medical records of 1 719 patients with ASD were collected，and the data table of acupuncture prescriptions was established with Excel 2019.Via the ancient and modern medical record cloud platform V2.2.3，Gephi 0.9，and Liquorice，hierarchical network analysis，cluster analysis，and association analysis were performed to explore the core acupuncture prescriptions for ASD.Results:The acupuncture prescriptions involved a total of 51 acupoints(acupuncture point areas)，which were mainly distributed in the 14 meridians，Jinsan point area，head point area，and extra point.The core prescriptions yielded by hierarchical network analysis included 17 core acupoints(acupuncture point areas):8 major acupoints(acupuncture point zones) of “Baihui”(GV 20)，“Shenmen” [TF(4)]，“Neiguan”(PC 6)，Four Spirit Points，3-Points for Intelligence，First Language Area，“Yongquan”(KI 1)，and “Naohu”(GV 17)，and 9 minor points(acupuncture point areas) of Third Language Area，Second Language Area，“Ganshu”(BL 18)，“Xuanzhong”(GB 39)，“Taichong”(LR 3)，“Xinshu”(BL 15)，“Shenshu”(BL 23)，“Taixi”(KI 3)，and “Sanyinjiao”(SP 6).Cluster analysis classified the high-frequency acupoints for the treatment of ASD by acupuncture into five categories:category 1 of “Baihui”(GV 20)，Third Language Area，Second Language Area，First Language Area，and Four Spirit Points，category 2 of “Neiguan”(PC 6) and “Shenmen” [TF(4)]，category 3 of “Naohu”(GV 17)，“Xuanzhong”(GB 39)，and “Yongquan”(KI 1)，category 4 of “Ganshu”(BL 18)，and category 5 of “Fengchi”(GB 20) and “Xinshu”(BL 15).Conclusion:The study found the rule in point selection for acupuncture treatment of ASD:Both body acupuncture and head acupuncture were performed，with body acupuncture mainly regulating the balance of the internal organs and head acupuncture modulating the spirit and for the symptomatic treatment.This study can serve a reference for point selection in the acupuncture treatment of ASD.