To explore the component-target-pathway regulatory network of Chinese herbal medicine Rhizoma Smilacis Glabrae in the treatment of psoriasis vulgaris by network pharmacology and with the help of R language.Methods:The active components and targets of Rhizoma Smilacis Glabrae were filtered by Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP) combined with literature research.The targets of psoriasis vulgaris were screened by GeneCards，Online Mendelian Inheritance in Man(OMIM)，Therapeutic Target Database(TTD)，PharmGkb and DrugBank.The drug component and disease targets were matched using the R language and the drug-component-key target-pathway network was established by Cytoscape 3.7.2.STRING was used to construct the protein-protein interaction(PPI) network，and the key genes were identified by the R language to draw the histogram.Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway enrichment analysis were conducted on the component-disease intersection targets.Results:There were 15 active components involving 325 valid targets and 86 pathways，among which 12 active components，114 target proteins and 20 key pathways were predicted to be associated with psoriasis vulgaris.Molecular docking displayed that the core components could well bind to the core targets.Conclusion:Rhizoma Smilacis Glabrae may play a role in the treatment of psoriasis vulgaris by acting on tumor necrosis factor(TNF) and IL-17 signaling pathways.This paper preliminarily revealed the potential active components and possible mechanism of Rhizoma Smilacis Glabrae in the treatment of psoriasis vulgaris，and provided theoretical basis for further experimental studies on the basis of pharmacological mechanism.