To screen out the action targets and related signal pathways of Rhizoma Sparganii-Rhizoma Curcumae drug pair on the treatment of liver cancer by means of network pharmacology，and to clarify the mechanism of action in the treatment of liver cancer.Methods:The effective ingredients and targets of Rhizoma Sparganii-Rhizoma Curcumae drug pair were screened out through the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP)，and the effective ingredient-target Protein-protein Interaction(PPI) network was constructed.We retrieved disease targets related to liver cancer from OMIM，DrugBank，and TTD databases，and used R language software analysis to obtain the intersection target of the Rhizoma Sparganii-Rhizoma Curcumae drug pair component and liver cancer.Cytoscape 3.2.1 software was used to draw the component-target network，and the DAVID database was used for Gene Ontology(GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway analysis.Results:A total of 31 targets of Rhizoma Sparganii-Rhizoma Curcumae drug pair turmeric medicine against liver cancer were screened.A total of 125 GO analyses related to liver cancer were involved，including 3 aspects:molecular function，biological process，and cell composition.There were 82 KEGG pathways，mainly from the positive regulation of nitric oxide biosynthesis，the cell's response to lipopolysaccharide，and the positive regulation of RNA polymerase Ⅱ promoter transcription to treat liver cancer.Conclusion:This study preliminarily verified the treatment of liver cancer by Rhizoma Sparganii-Rhizoma Curcumae drug pair through the tumor necrosis factor signaling pathway，the positive regulation of RNA polymerase Ⅱ promoter transcription，and the steroid hormone-mediated signaling pathway.This study shows that the Rhizoma Sparganii-Rhizoma Curcumae drug pair has the characteristics of multiple components and multiple targets，and its mechanism of action is diverse，which provides a reference for further research on the treatment of liver cancer.