Fatigue has become an important factor affecting people's quality of life.With high incidence，fatigue can be regarded as an independent disease and is a symptom of a variety of chronic diseases.Since many clinical drugs have common side effects，effective prevention and treatment of fatigue has become an urgent problem to be solved.As the pathogenesis of fatigue is complex，western medicines lack an effective and complete program and have the risk of addiction and side effects.Chinese medicines for resisting fatigue boast the unique advantages of safety，effectiveness and synergistic effect.It is of great significance to explore the safe and effective Chinese medicines for treating fatigue.Liver，spleen and kidney dysfunction is an important pathogenesis of fatigue，and most of Chinese prescriptions for treating fatigue are mainly soothing liver，invigorating spleen and tonifying kidney.The mechanism of improving fatigue by Chinese medicines includes reducing the accumulation of metabolites，improving neuroimmune inflammatory reaction，and regulating immune function，energy metabolism，HPA axis function and synthesis and release of neurotransmitters in the brain，with antioxidant activity.This article systematically and comprehensively summarized and analyzed the core pathogenesis of fatigue，anti-fatigue Chinese medicine prescriptions，and the mechanism of anti-fatigue by Chinese medicine，so as to provide a basis for comprehensive and in-depth discussion on the anti-fatigue mechanism of Chinese medicines and the effective prevention and treatment.