| 引用本文:唐仕欢1，常梦丽1，张晶晶1，杨洪军2.基于缺血性中风“体病同治”策略探讨杜蛭丸临床再定位[J].世界中医药,2022,(07):. |
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| 基于缺血性中风“体病同治”策略探讨杜蛭丸临床再定位 |
| Clinical Re-orientation of DuZhi Wan in Treating Ischemic Stroke Based on the Strategy of “Simultaneous Treatment of Constitution and Disease” |
| 投稿时间：2022-03-10 |
| DOI：10.3969/j.issn.1673-7202.2022.07.001 |
| 中文关键词: 缺血性中风 体病同治 杜蛭丸 临床再定位 |
| English Keywords:Ischemic stroke Simultaneous treatment of constitution and disease DuZhi Wan Clinical re-orientation |
| 基金项目:国家重点研发计划项目(2018YFC1704101;2019YFC1708904);中国中医科学院科技创新工程项目(CI2021A03705;CI2021A00605) |
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| 中文摘要: |
| 中风是当今多发重大疾病,降低该病的发病率、致残率和复发率是临床的重要课题。中成药应用是中风防治的有效手段之一,但中成药品类繁多,临床适应证宽泛,应用“中医理论-临床实践-基础研究”三维整合技术可以实现中成药临床再定位及其评价,挖掘品种的组方内涵和特点,进一步明确其临床定位和优势,为更好地发挥其临床价值具有现实意义。本文总结中风的病因病机认识,提出体质虚损是缺血性中风发病前提,并贯穿整个发病轴,在发病前期、急性发作期、恢复期、后遗症期均存在,仅是凸显程度不同,气虚血瘀是发病核心病机,“体病同治”是有效防治策略。在此基础上,以中成药杜蛭丸为范例,分析该品种的组方特点,发现符合“体病同治”的防治策略,在中医理论指导下分析其临床再定位,并提出进一步的研究思路与路径。基于中医理论、临床实践、基础研究有机结合,将实现品种的临床再定位和评价,为中风防治和中成药的临床再定位研究提供示范。 |
| English Summary: |
| Stroke is a major disease with high incidence rate nowadays.It is an important clinical project to reduce the incidence rate，mortality rate，and recurrence rate of stroke.The application of Chinese patent medicines is one of the effective methods to treat and prevent stroke，but there are many complex varieties of Chinese patent medicines，which have a wide range of clinical indications.The application of three-dimensional integration technology of “traditional Chinese medicine(TCM) theory-clinical practice-basic research” can achieve clinical re-orientation and re-evaluation，explore the connotations and characteristics，and further specify clinical re-orientation and advantages of Chinese patent medicines，which has practical significance for better exerting the clinical value.Summarizing the pathogenesis and mechanism of stroke，this study proposed that deficient constitution was the pathogenic premise of stroke and ran through the whole pathogenic stages with different degrees such as the premorbid stage，acute attack stage，recovery stage，and sequelae stage.Qi deficiency and blood stasis were the core mechanism of stroke.The strategy of “simultaneous treatment of constitution and disease” was effective to treat and prevent stroke.This study took DuZhi Wan，a Chinese patent medicine，as an example to analyze the prescription characteristics of DuZhi Wan corresponding to the strategy of “simultaneous treatment of constitution and disease”.The clinical re-orientation of DuZhi Wan was analyzed under the guidance of TCM theory，and the research idea and path were further proposed.The combination of TCM theory，clinical practice，and basic research will realize the clinical re-orientation and evaluation of varieties of Chinese patent medicines，which provides a demonstration for the prevention and treatment of stroke and the clinical re-orientation of Chinese patent medicines. |
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