To predict the targets of Maziren Pills in the treatment of postoperative ileus(POI) by network pharmacology and explore its multi-component，multi-target，and multi-pathway mechanism.Methods:The chemical components of Maziren Pills were collected from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP)，and the effective components were obtained according to oral bioavailability(OB) and drug-likeness(DL)，followed by the prediction of targets of the effective components.POI-related targets were retrieved from GeneCards，OMIM，and DisGeNet.After the common targets were obtained，the component-target interaction network was constructed by Cytoscape 3.7.2.The protein-protein interaction(PPI) network was plotted by using String.The core targets were docked to core components.Metascape was used for Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) enrichment analyses.Results:A total of 405 POI-related targets,140 active components of Maziren Pills,and 75 therapeutic targets were obtained.As revealed by GO enrichment analysis,biological processes involved response to inorganic substance,response to hazardous substance,cellular response to the drug,cytokine-mediated signaling pathway,response to lipopolysaccharide,response to oxidative stress,response to molecule of bacterial origin,positive regulation of kinase activity,positive regulation of transferase activity,etc.As revealed by KEGG enrichment analysis,pathways involved the PI3K-AKT signaling pathway,TNF signaling pathway,HIF-1 signaling pathway,IL-17 signaling pathway,ErbB signaling pathway,etc.Conclusion:Maziren Pills can improve postoperative intestinal obstruction inflammation,regulate intestinal mucosal immunity and intestinal microcirculation through multiple potential pathways,multiple targets and multiple pathways.