With the increase in the aging population in China,the incidence of Parkinson's disease is getting higher,and the number of patients with Parkinson's disease complicated with depression is also gradually increasing in clinical practice.Through clinical observation,Parkinson's disease complicated with depression is prone to occur in the elderly,and liver and kidney deficiency is important pathogenesis of Parkinson's disease complicated with depression.Clinical practice shows that the treatment of Parkinson's disease with depression from the liver and kidney theory has achieved good results.This article discussed the relationship of liver and kidney with Parkinson's disease and depression and introduced medication protocols for the treatment of Parkinson's disease with depression from the liver and kidney theory based on clinical cases.