复方益母胶囊对药物流产后凝血功能的影响
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国家自然科学基金项目(81373514);河北省中医药管理局计划项目(2019045)


Effect of Fufang Yimu Capsules on Coagulation Function after Medical Abortion
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    摘要:

    目的:观察复方益母胶囊对药物流产后凝血功能的影响。方法:选取2019年1月至2020年12月河北省中医院收治的接受药物流产的患者100例作为研究对象,按照随机数字表法分为对照组和观察组,每组50例。对照组患者采用常规药物,观察组在对照组的基础上加用复方益母胶囊,比较2组患者的凝血功能指标,观察2组患者的流产情况、阴道流血时间、月经恢复时间、临床疗效及不良反应。结果:药物流产前,2组患者的血浆纤维蛋白原(Fib)、D-二聚体(D-D)、国际标准化比值(INR)、血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、抗凝血酶(AT)水平比较,差异无统计学意义(P>0.05)。治疗后,观察组患者的PT、APTT、TT、AT水平均高于对照组,Fib、D-D、INR水平均低于对照组(P<0.05);观察组患者的完全流产率、总有效率高于对照组(P<0.05);观察组患者的阴道流血时间、不良反应总发生率均低于对照组(P<0.05);2组患者的月经恢复时间比较,差异无统计学意义(P>0.05)。结论:复方益母胶囊可明显改善药物流产后患者的凝血功能,有效提高流产的成功率,可在临床广泛使用。但研究的病例数较少,数据存在一定不足。

    Abstract:

    To investigate the effect of Fufang Yimu Capsules on the coagulation function of the patients after medical abortion.Methods:A total of 100 patients who received medical abortion in the Hebei Provincial Hospital of Traditional Chinese Medicine from January 2019 to December 2020 were enrolled and divided into a control group(n=50) and an observation group(n=50) according to a random number table.All patients were treated with conventional western medicine,while those in the observation group received additional Fufang Yimu Capsules.The coagulation function indexes of the two groups were compared.The abortion,vaginal bleeding time,menstrual recovery time,clinical efficacy,and adverse events of the two groups were observed.Results:Before the medical abortion,there was no statistically significant difference in plasma fibrinogen(Fib),D-dimer(D-D),international normalized ratio(INR),prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT),and antithrombase(AT) levels between the two groups(P>0.05).After treatment,the levels of PT,APTT,TT,and AT in the observation group were higher than those in the control group,while the levels of Fib,D-D,and INR were lower than those in the control group(P<0.05).The rate of complete abortion and total effective rate in the observation group were higher than those in the control group(P<0.05).The vaginal bleeding time and total incidence of adverse events in the observation group were lower than those in the control group(P<0.05).There was no statistically significant difference in menstrual recovery time between the two groups(P>0.05).Conclusion:Fufang Yimu Capsules can improve the coagulation function of patients after medical abortion and improve the success rate of abortion,which can be widely used in clinical practice.However,the data were insufficient due to the small sample size in this study.

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秦玉璇,云凤,司军莉,许莉,边文会,高晓静.复方益母胶囊对药物流产后凝血功能的影响[J].世界中医药,2022,(07).

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  • 收稿日期:2011-11-29
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  • 在线发布日期: 2022-05-26
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