| 引用本文:李硕，刘清泉.中药灌肠辅助改善脓毒症急性肾损伤的随机对照试验[J].世界中医药,2022,(07):. |
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| 中药灌肠辅助改善脓毒症急性肾损伤的随机对照试验 |
| Randomized Controlled Trial of Chinese Medicine Enema as an Aid to Improve Sepsis-associated Acute Kidney Injury |
| 投稿时间：2022-02-16 |
| DOI：10.3969/j.issn.1673-7202.2022.07.024 |
| 中文关键词: 脓毒症急性肾损伤 中药 灌肠 疗效 安全性 血肌酐 肾小球滤过率 |
| English Keywords:Sepsis-associated acute kidney injury Chinese medicine Enema Efficacy Security Serum creatinine Glomerular filtration rate |
| 基金项目:北京市自然科学基金项目(7192083) |
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| 中文摘要: |
| 目的:观察中药灌肠辅助改善脓毒症急性肾损伤(S-AKI)的疗效及安全性。方法:选取2019年1月至2020年6月首都医科大学附属北京中医院收治的S-AKI患者60例作为研究对象,按照随机数字表法随机分为对照组和观察组,每组30例。对照组采用常规治疗及100 mL 0.9%生理盐水灌肠,1次/d,连续4 d。观察组在常规治疗的基础上加用中药100 mL灌肠1次/d,连续4 d,观察2组患者治疗前、治疗4 d、7 d后血肌酐(Scr)、肾小球滤过率(GFR)、尿素氮(BUN)、24 h尿量、白细胞(WBC)、C反应蛋白(CRP)、谷丙转氨酶(GPT)、谷草转氨酶(GOT)等指标的变化情况。结果:观察组患者治疗4 d、7 d后的Scr、BUN较对照组下降,GFR、24 h尿量较对照组增加,差异有统计学意义(P<0.05)。观察组治疗4 d、治疗7 d的CRP较对照组明显下降,WBC、GPT、GOT的差异无统计学意义。结论:中药灌肠可以辅助降低S-AKI患者的Scr、BUN,增加GFR、24 h尿量,对患者的肾脏起到辅助保护作用,该方法可降低CRP,可辅助抑制炎症反应,同时该方法未增加肝脏负担,具备一定的安全性。 |
| English Summary: |
| To observe the efficacy and safety of Chinese medicine enema on improving sepsis-associated acute kidney injury(S-AKI).Methods:A total of 60 cases of S-AKI from January 2019 to June 2020 in Beijing Hospital of Traditional Chinese Medicine were selected and divided into an observation group and a control group by the random number table method，with 30 cases in each group.The control group was given conventional treatment combined with 100 mL of 0.9% normal saline enema，once per day for four days.The observation group was given 100 mL of Chinese medicine enema based on the conventional treatment，once per day for four days.The 24 hour urine volume，serum creatinine(Scr)，glomerular filtration rate(GFR)，urea nitrogen(BUN)，glutamic-pyruvic transaminase(GPT)，glutamic-oxaloacetic transaminase(GOT)，white blood cell(WBC)，and C-reactive protein(CRP) were observed before treatment and after treatment for four days and seven days.Results:After four-day and seven-day treatment，compared with the control group，Scr and BUN were decreased，and GFR and 24-hour urine volume were increased in the observation group，with statistical significance(P>0.05).The CRP level of the observation group was significantly lower than that of the control group after four-day and seven-day treatment.The difference in WBC，GPT，and GOT had no statistical significance.Conclusion:Chinese medicine enema assisted in reducing Scr and BUN，and increasing GFR and 24-hour urine volume of S-AKI patients，which had a protective effect on kidney of S-AKI patients.Chinese medicine enema reduced CRP level by assisting in inhibiting inflammatory response，and had a certain safety since it did not increase the burden on the liver. |
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