To systematically analyze the compatibility regularity of acupoints in the treatment of tumors based on modern literature by data mining technology.Methods:Research articles published from 1980 to 2020 on the treatment of tumors by acupuncture were retrieved from CNKI，CSPD，and CCD and analyzed for the acupoint selection and compatibility regularity by the Traditional Chinese Medicine Inheritance Support System.Results:Thirty-two research articles were obtained.As revealed by modern research articles，the acupoints are selected according to the attribute，meridian，and position.Acupoint compatibility is dominated by exterior-interior meridian compatibility，specific combinations，and heaven-human-earth acupoint combinations.In acupuncture and moxibustion，tumors are mainly treated with three-acupoint and multi-acupoint prescriptions.Conclusion:The present study summarized the acupoint selection and compatibility regularity of acupuncture and moxibustion in the treatment of tumors.The appropriate selection of acupoints for compatibility is beneficial to strengthen the synergic effect between acupoints，enhance the clinical effect of acupuncture and moxibustion，and promote the clinical application of acupuncture and moxibustion.