According to the visceral manifestation theory in traditional Chinese medicine，the heart is likened to a monarch，which governs mental activity，coordinates zang-fu organs，and supports life activities.It excels in obstructing and clearing.If the heart is abnormal in function，all the twelve organs will be in danger and cannot function well，inevitably resulting in severe damage of the body.This may be related to the occurrence and metastasis of tumor.The atrial natriuretic peptide secreted by the heart is one of the material foundations for governing the twelve organs.This hormone is related to various malignant biological behaviors such as tumor cell proliferation and metastasis，and angiogenesis.The intemperance of changes in seven emotions caused by “heart failing to control mental activity” also has important impact on the incidence of cancer.Emotional disorders may promote tumor recurrence and metastasis，and negative emotions may affect the secretion of atrial natriuretic peptide.Therefore，in the treatment of tumors，in addition to reinforcing healthy qi and detoxifying，suppressing tumors and anti-cancer，we should emphasize the nourishing and protection of the heart.The heart-nourishing formulas and medicinals can not only alleviate the symptoms but also adjust the anti-tumor immunity in the treatment of tumors.According to the theory of traditional Chinese medicine and modern research outcomes，this study aims to discuss the influence of heart and heart functions on tumors based on “heart failing to control mental activity”，with a view to laying a theoretical basis for the treatment of tumors by traditional Chinese medicine.